mRNA CAR T therapy Descartes‑08 targets BCMA‑positive plasma cells and delivers year‑long symptom relief in myasthenia gravis after a brief course, signaling a new era of durable treatment.
Category: 8. Health
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CAR T Promises Longer Relief For Myasthenia Gravis
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Scientists found a hidden fat switch and turned it off
Scientists at Cleveland-based institutions have uncovered a surprising new switch that helps the body make fat — and turning it off had dramatic effects.
- Obesity and fatty liver disease are becoming more common worldwide as diets grow more…
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Why colorectal cancer breaks the immune system’s rules
In most solid tumors, large numbers of regulatory T (Treg) cells are linked to worse outcomes. These immune cells normally act as brakes on the immune system, which means they can weaken the body’s ability to attack cancer.
Colorectal cancer…
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Congress passes $50 billion foreign aid bill : NPR
Remnants of signage for the US Agency for International Development (USAID) on the facade of the Ronald Reagan Building and…
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The truth (and false positives) of TB diagnosis : NPR
A woman diagnosed with tuberculosis receives care at Barawe General Hospital in Somalia.
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New DNA-based vaccine scaffolds boost targeted immune responses to HIV
One of the biggest hurdles in developing an HIV vaccine is coaxing the body to produce the right kind of immune cells and antibodies. In most vaccines, HIV proteins are attached to a larger protein scaffolding that mimics a virus….
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Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells | Science Immunology
Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.
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Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells | Science Immunology
Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and drive T cell exhaustion.
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Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis | Science Immunology
Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response.
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Immunobiology of the serous cavities | Science Immunology
Local immune function and cross-tissue communication in the serous cavities are reviewed.
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