Acarbose is a potential therapeutic agent for podocyte injury and glomerular lesions in diabetic nephropathy by acting as a USP46 agonist.
Category: 8. Health
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Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activation | Science Translational Medicine
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Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation | Science Translational Medicine
Functional reconstitution of the endometrium occurs after both uterus and HSC transplantation, and male immune cells can replenish the uterine niche.
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Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications | Science Translational Medicine
NFAT blockade in uterus transplant disrupts uterine NK tissue residency and associates with placental histopathology and pregnancy complications.
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Aberrant bone marrow granulopoiesis generates neutrophils that promote B cell activity in neuromyelitis optica spectrum disorder | Science Translational Medicine
Aberrant bone marrow granulopoiesis in NMOSD leads to increased output of BAFF-producing neutrophils that can drive AQP4-IgG production.
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Tac-kling tissue-resident uterine NK cells | Science Translational Medicine
After human uterus transplant, all uterine immune cell lineages were reconstituted but with alterations in tissue-resident NK cells, potentially due to tacrolimus (Asiimwe et al. and Strunz et al., this issue).
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Why Losing Measles Elimination Status Would Be A Big Deal In The U.S.
The U.S. losing measles elimination status could have a series of major implications for public health going forward.
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Fat cells burn energy to make heat – making them the next frontier of weight loss therapies
Over the past few years, a new class of medications has transformed the treatment of obesity. Drugs like Ozempic, Wegovy and Mounjaro work primarily by reducing appetite, helping people eat less and feel full sooner. Their success has…
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Beyond Muscles: Scientists Uncover Exercise’s Secret Brain-Boosting Power
Endurance improvements from exercise depend on sustained activation of specific brain neurons after workouts. Exercise does more than build stronger muscles. It also reshapes activity in the brain. In a study published in the Cell Press journal…
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How Tear Gas Affects Health — A Toxicologist Explains
Federal agents’ heavy use of tear gas is raising concern about harmful effects to protestors and neighborhoods. A toxicologist explains what it is and its health effects.
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Scientists Discover Simple Saliva Test That Reveals Hidden Diabetes Risk
Researchers have identified a potential new way to assess metabolic health using saliva instead of blood. High insulin levels in the blood, known as hyperinsulinemia, can reveal metabolic problems long before obvious symptoms appear. It is…
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