Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-09924-w
A simulation approach is used to ascertain the limitations on the structural and chemical information that atomic-resolution electron tomography can determine from noisy…
Category: 1. Edi-Choice
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Limit of atomic-resolution-tomography reconstruction of amorphous nanoparticles
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Intestinal macrophages modulate synucleinopathy along the gut–brain axis
Mice
All experiments were performed in accordance with the UK Animals (Scientific Procedures) Act 1986 and following local ethical advice. Experimental procedures were approved by the UK Home Office and ethical approval was granted through…
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PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Cell culture
The human U2OS osteosarcoma cell line (ATCC, HTB-96), HeLa Kyoto cervical carcinoma cell line (CVCL_1922), primary immortalized retinal epithelial cell line hTERT-RPE1 (ATCC, CRL-4000), primary immortalized foreskin fibroblast BJ…
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Six highlights from lung-health research
Heavy smog caused by pollution covers Lahore in Pakistan.Credit: Arif Ali/AFP via Getty Images
Next-generation air-quality analysis
Air pollution is the fifth-leading risk to health globally, according…
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Vacuum ultraviolet second-harmonic generation in NH<sub>4</sub>B<sub>4</sub>O<sub>6</sub>F crystal
Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10007-z
The fluorooxoborate crystal NH4B4O6F shows promise as a nonlinear optical material for vacuum ultraviolet light sources through second-harmonic generation, demonstrating record…
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Holistic motor control of zebra finch song syllable sequences
Animals
The experiments described in this study were conducted using adult male zebra finches (Taeniopygia guttata; 120–500 days post-hatch). All procedures were performed in accordance with protocols approved by the Animal Care and Use…
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Robust cytoplasmic partitioning by solving a cytoskeletal instability
Husbandry of experimental animals
Female frog (X. laevis) adults and zebrafish adults were maintained and handled according to established protocols43,44. Frogs were acquired from Nasco (LM00531) and Xenopus1 (4800). The experiments were approved…
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Cholinergic modulation of dopamine release drives effortful behaviour
Subjects
Male and female mice of C57BL/6J background (Jackson Laboratories, strain 000664) were used in approximately equal numbers for all experiments. Wild-type mice were crossed with DAT:IRES–Cre mice (Jackson Laboratory, strain 006660) or…
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The Ocean Equity Index | Nature
Jacquemont, J., Blasiak, R., Le Cam, C., Le Gouellec, M. & Claudet, J. Ocean conservation boosts climate change mitigation and adaptation. One Earth 5, 1126–1138 (2022).
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Environmentally driven immune imprinting protects against allergy
Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10001-5
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a…
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