Cell lines and culture methods
All cell lines were cultured in a humidified incubator under normoxia at 37 °C with 5% CO2. Cell lines were validated by STR analysis and were routinely screened and tested negative for mycoplasma.
Category: 1. Edi-Choice
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Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes
UKB resource
The protocols for the UKB are overseen by the UKB Ethics Advisory Committee; for more information, see https://www.ukbiobank.ac.uk/ethics and https://www.ukbiobank.ac.uk/wp-content/uploads/2025/01/Ethics-and-governance-framework.pdf….
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Atmospheric H2 variability over the past 1,100 years
Warwick, N., Griffiths, P., Keeble, J., Archibald, A., & Pyle, J. Atmospheric implications of increased Hydrogen use. GOV.UK https://www.gov.uk/government/publications/atmospheric-implications-of-increased-hydrogen-use (2022).
Derwent, R. G. et…
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Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis
Mice and in vivo procedures
KrasLSL−G12D/+; p53fl/fl (KP) mice have been described previously55. KP mice were crossed with Rosa26LSL−tdTomato mice to generate KP; LSL-tdTomato mice. Wild-type C57BL/6 J, Trpv1-cre, Rosa26LSL−DTR (LSL-DTR),…
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Biodiversity conservation has an evidence problem — it’s time to fix it
Studies from Himachal Pradesh in northern India (pictured) have found that tree-planting schemes have not increased forest canopy cover.Credit: Pallava Bagla/Getty
Biodiversity loss is continuing at an…
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Atlas-guided discovery of transcription factors for T cell programming
Dataset acquisition for mouse CD8+ T cell state multi-omics atlas
CD8+ T cell samples were collected from ten datasets, including those generated in this study (Extended Data Fig. 1e). In total, we analysed 121 experiments, comprising 52…
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Bacterial immune activation via supramolecular assembly with phage triggers
Strains and growth conditions
All bacterial and phage strains used in this study are listed in Supplementary Table 2. E. coli strains were routinely grown at 37 °C in Luria–Bertani (LB) medium for cloning and maintenance. Phages were…
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Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness
Mouse strains and mutants
Mice (wild-type C57BL/6J, IMSR, JAX: 000664, RRID: IMSR_JAX:000664; Miwi−/− mutation, MGI: 2182488; and pachytene piRNA mutations listed in Supplementary Table 1) were housed and euthanized according to the guidelines of the…
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Evolutionary insights into a skin fold
Nature, Published online: 04 February 2026; doi:10.1038/d41586-026-00171-1
The formation of a skin fold named a rete ridge reveals how simple architectural changes reshape tissue mechanics and signalling routes to make a different type of skin…
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PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling
Hopfner, K.-P. & Hornung, V. Molecular mechanisms and cellular functions of cGAS–STING signalling. Nat. Rev. Mol. Cell Biol. 21, 501–521 (2020).
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Sun,…
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