Shaker Kv channel expression
To produce the Shaker Kv channel for cryo-EM, the full-length gene was cloned into the pEG vector in which eGFP was substituted with mVenus56 to produce constructs with the mVenus tag on either the C or N terminus and…
To produce the Shaker Kv channel for cryo-EM, the full-length gene was cloned into the pEG vector in which eGFP was substituted with mVenus56 to produce constructs with the mVenus tag on either the C or N terminus and…
A non-toxic, robust and solution-processable…
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Alzheimer’s disease, which represents 60–80% of dementia cases1, robs people of their memory, cognition and independence. A decade-long period of mild cognitive impairment precedes the onset of…
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A genome-wide analysis has identified genetic variants…
Post-mortem human brain and serum samples were obtained in accordance with institutional guidelines and with approval from the Harvard Medical School Institutional Review Board. All procedures complied with relevant ethical…
A slice from a normal human brain (left, artificially coloured) contrasts with a slice from the brain of a person with Alzheimer’s disease.Credit: Jessica Wilson/Science Photo Library
Replenishing the brain’s natural stores of lithium can…
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Kotz, M., Levermann, A. & Wenz, L. The economic commitment of climate change. Nature 628, 551–557 (2024).
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