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Golzari-Sorkheh, M., Yoganathan, K., Chen, E. L. Y., Singh, J. & Zúñiga-Pflücker, J. C. in Thymus Transcriptome…
Category: 1. Edi-Choice
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Synthetic circuits for cell ratio control
Bacterial strains and culture conditions
All cloning was performed in E. coli Trans1-T1 chemically competent cells (TransGen Biotech). Genetic circuit validation used E. coli DH10B (TSC-C09, Tsingke). Cultures were grown in lysogeny broth (LB) at…
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An enzyme inside the bacterial-cell membrane chops up viral DNA on entry
- RESEARCH BRIEFINGS
When a virus infects a bacterial cell, the viral genome…
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Climate snapshots trapped in ancient ice tell a surprising story
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00636-3
Antarctic ice cores hint that changes in the ocean might have played a larger part than have greenhouse gases in key climate shifts of the past three million years.
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Our microbial ancestors were probably oxygen-tolerant
- RESEARCH BRIEFINGS
Genomic analysis has unexpectedly revealed that…
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The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Plasmids
Cloning was performed either by Gibson assembly with the NEBuilder HiFi DNA Assembly Master Mix (New England Biolabs (NEB), E2621) or by site-directed mutagenesis by direct PCR with the KAPA HiFi HotStart Ready Mix (Roche, 07958935001) or…
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Thymic health and immunotherapy outcomes in patients with cancer
In this study we provide evidence for the clinical relevance of thymic health in immuno-oncology. We found that high thymic health was consistently associated with improved outcomes across a real-world cohort of 3,476 patients with various cancer…
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Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals
Serial EM reconstructions
EM reconstructions were based on a single animal. We previously imaged and aligned a 770 × 750 × 53-μm3 volume of lobule V of the mouse cerebellum for EM reconstructions composed of 1,176 45-nm-thick…
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Integrated photonic neural network with on-chip backpropagation training
Shastri, B. J. et al. Photonics for artificial intelligence and neuromorphic computing. Nat. Photon. 15, 102–114 (2021).
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McMahon, P. L. The physics of…
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Genome editing that avoids immune detection to integrate large DNA sequences
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00730-6
A genome-editing approach called INSTALL combines single-stranded DNA molecules that evade immune detection with a short double-stranded region that allows recombinase enzymes to…
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