The frequency of NRG1 fusions across solid tumor types
We collected next-generation sequencing (NGS) data from tumor samples from 25,203 patients across 15 types of solid tumors (Table 1). Among these patients, 49 patients with NRG1 fusions were…
Category: 5. Biology
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Intraepithelial T cells move from gut to breast to shape lactation
Intraepithelial T cells move from gut to breast to shape lactation
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The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens
Sati, H. et al. The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance. Lancet Infect. Dis. 0,
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Six degrees of TGFβ | Nature Immunology
Skon, C. et al. Nat. Immunol. 14, 1285–1293 (2013).
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Mora-Bunch, R. et al. Nat Immunol. https://doi.org/10.1038/s41590-025-02207-6 (2025).
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Carboxylation switch | Nature Immunology
Activation of mitochondrial antiviral signaling protein (MAVS) at the mitochondria membrane mediates both interferon (IFN) and apoptosis responses. In Science, Okazaki et al. show that carboxylation of MAVS enhances type I IFN responses and…
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Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development
The miR-200 family is required during early cardiac development
To determine if miR-200 is a key player in mammalian cardiac development, we profiled miR-200 family expression from embryonic mouse whole heart RNA. Transcripts encoding the miR-200…
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Intermittent fasting and a no-sugar diet for Long COVID symptoms: a randomized crossover trial
Al-Aly, Z. et al. Long COVID science, research and policy. Nat. Med. 30, 2148–2164 (2024).
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Peluso, M. J. & Deeks, S. G. Mechanisms of long COVID and the path toward therapeutics….
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Enhancing adoptive cell therapy: future strategies for immune cell radioprotection in neuro-oncology
Adoptive cell therapy (ACT) including chimeric antigen receptor (CAR) T-cell therapy has shown promising early signals of activity in treating select patients with brain tumors1. ACT is a type of immunotherapy that uses a patient’s own immune…
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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights
Patient characteristics
A total of 186 patients with DLC were screened from March 2022 to March 2024. The study comprised two stages (Phases Ia and Ib), as shown in Fig. 1. Phase Ia enrolled 15 patients who received MSC infusions following a…
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Cultivar specific nitrogen and potassium recommendations optimize yield and quality attributes in sugar beet
Variation in yield and quality traits among sugar beet cultivars
The performance of five sugar beet cultivars (Indira, Carma, Mallak, Melodia, and Shantala) was evaluated across ten yield and quality traits (Fig. 1). Significant variations were…
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