The T cell receptor (TCR) is a protein expressed on the surface of T cells that is critical in the detection of diverse antigens and in the initiation of immune responses. TCRs are composed of alpha (α) and beta (β), or gamma (γ) and delta…
Category: 5. Biology
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Why genomic diversity should not be framed by census alone
Efforts to increase diversity in genomics datasets often default to proportional representation based on global census figures1. This approach equates inclusion with demographic parity, overlooking the scientific and ethical dimensions of…
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Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
This study complies with all relevant ethical regulations, as detailed below. A complete list of all antibodies, RNAi, CRISPR and RT-qPCR reagents is available in Supplementary Information.
Clinical specimens
Use of breast cancer samples was…
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Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Ethical statement
HUES66 was derived at Harvard University, where ethics approval was obtained prior to its registration with NIH under NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0057. The New York Genome Center cannot speak to the consent…
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Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
Experimental model and study participant details
Human participants
This project was approved by the Institutional Review Board of UT Southwestern Medical Center and complied with all relevant ethical regulations. Recruitment of human participants…
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A novel nanoparticle vaccine displaying multistage tuberculosis antigens confers protection in mice infected with H37Rv
Hosseinpoor, A. R. et al. Monitoring inequalities is a key part of the efforts to end AIDS, tuberculosis, and malaria. Lancet 399, 1208–1210 (2022).
Fernandes, G. F. S., Thompson, A. M.,…
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Evolution of antifungal resistance in the environment
Fisher, M. C. et al. Emerging fungal threats to animal, plant and ecosystem health. Nature 484, 186–194 (2012).
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Denning, D. W. Global incidence and mortality of severe…
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Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency
Waldman, A. D., Fritz, J. M. & Lenardo, M. J. Nat. Rev. Immunol. 20, 651–668 (2020).
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Schenkel, J. M. & Pauken, K. E. Nat. Rev. Immunol. 23, 807–823 (2023).
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Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels
The modeled architectures of LmOR35-Orco under various stoichiometric ratios
Due to the lack of experimental structures of locust odorant receptors, we evaluated the predicted models using AF3 modeling and homology modeling, respectively. We found…
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Returning home to navigate challenges and meet potential in Poland
Returning home to navigate challenges and meet potential in Poland
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