Mouse strains, influenza infection and antibody treatments
Transgenic mouse models of breast cancer, using mouse mammary tumour virus (MMTV) long terminal repeats, are widely used. In brief, MMTV-PyMT and MMTV-erbB2/neu/Her2 (MMTV-Her2) mice…
Category: 5. Biology
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Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model
Cells
The HeLa cell was obtained from the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. The GSDME KO HeLa cell line was provided by Dr Feng Shao (Chinese Academy of Biological Sciences, Beijing). The KHDRBS1 KO and DDX5…
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Assessing alpha lattice design for heat stress indices and yield stability in wheat genotypes
Assessment of heat stress indices
Heat stress indices are quantitative tools, widely used to examine the impacts of heat stress on plant growth and development28. Stress indices are crucial tools for assessing physiological and yield-related…
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CRISPR-GPT for agentic automation of gene-editing experiments
Building AI co-pilot harnessing LLM’s reasoning ability
CRISPR-GPT supports four major gene-editing modalities and 22 gene-editing experiment tasks (Fig. 1 and Supplementary Table 1). It offers tunable levels of automation via three modes: Meta,…
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Shortcomings of silhouette in single-cell integration benchmarking
Integrating single-cell data remains a key challenge because of increasing dataset complexity and volume. These datasets comprise batch effects arising from technical factors (for example, assays and protocol), alongside meaningful biological…
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Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind
Yeung, N. & Summerfield, C. Metacognition in human decision-making: confidence and error monitoring. Philos. Trans. R. Soc. B Biol. Sci. 367, 1310–1321 (2012).
Stone, C., Mattingley, J. B. &…
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Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects
Cell confinement induces a mitochondrial enrichment at the nucleus
To explore cellular adaptation mechanisms to mechanical stress in specific cell compartments and organelles, we performed a subcellular fractionation of HeLa cells acutely confined…
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Lycium barbarum glycopeptide mitigates retinal ischemia-reperfusion injury through its anti-inflammatory, anti- senescence, and anti-apoptosis properties
Weinreb, R. N., Aung, T. & Medeiros, F. A. The pathophysiology and treatment of Glaucoma A review. The J. Am. Med. Association. 311, 1901–11 (2014).
Bicket, A. K. et al. Minimally invasive Glaucoma surgical techniques for Open-Angle Glaucoma an…
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