Scripps scientists show that ribose may have been nature’s preferred sugar for building RNA, offering new insight into how life’s molecular foundations may have formed before biology began. Today, cells rely on enzymes to assemble complex…
Category: 5. Biology
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Where Did RNA Come From? Scientists Find a Chemical Clue
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Drones reveal 41,000-turtle nesting mega-site hidden in the Amazon
A University of Florida research team has developed a more accurate way to count wildlife using drones — an innovation that helped confirm the world’s largest known nesting site for a threatened turtle species.
By combining aerial imagery with…
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Food reward entrainment increases mealtime anxiety in goldfish via a ghrelin-dependent mechanism
Albrecht, U. Timing to perfection: The biology of central and peripheral circadian clocks. Neuron 74, 246–260. https://doi.org/10.1016/j.neuron.2012.04.006 (2012).
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AI expands the repertoire of CRISPR-associated proteins for genome editing
AI expands the repertoire of CRISPR-associated proteins for genome editing
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Real-world assessment of thromboembolic risk associated with tamoxifen
It has been demonstrated in early clinical studies18 that tamoxifen use is associated with increased mortality from stroke and pulmonary embolism. In the present study, demographics, temporal trends, and clinical heterogeneity of TAM-associated…
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Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study
Genome-wide association studies of serum vitamin B12 and folate levels
Total serum vitamin B12 levels were measured in three cohort studies18. GWAS meta-analyses were performed based on a total of 45,576 participants of European ancestry,…
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The tiny mouse lemur could make for a mighty model organism
Advances in genomic technologies have paved the way for new model organisms to enhance scientists’ understanding of primate biology. In a pair of pioneering studies published in Nature, the Tabula Microcebus Consortium et al.1, and Ezran et…Continue Reading
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Ambient temperature influenced co-expression network of major developmental, circadian, and photoreceptor genes in bread wheat
McClung, C. R. Circadian clock components offer targets for crop domestication and improvement. Genes 12, 374 (2021).
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Trevaskis, B., Bagnall, D. J., Ellis, M. H., Peacock, W. J. &…
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Author Correction: HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Targeting the proliferation of glioblastoma cells and enhancement of doxorubicin and temozolomide cytotoxicity through inhibition of PFKFB4 and HMOX1 genes with siRNAs
Assessment of cytotoxic activity in U87-MG cells through in vitro assays
Dose-dependent viability assay for each siRNA (siPFKFB4, siHMOX1, and Scrambled), as well as both siPFKFB4/siHMOX1 was performed with serial doses of siRNAs ranging from 0.8…
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