CRISPR–Cas9 has been widely used to study fundamental biological processes, including DNA metabolism, development, physiology and pathology. Cheng et al. review how CRISPR–Cas9 has been utilized as a genome modification tool to introduce…
Category: 5. Biology
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A chromosome-level genome assembly of Guimi No. 2 (Actinidia chinensis)
Materials collection and sequencing
Fresh young leaves used for genome sequencing were collected from the A. chinensis var. chinensis ‘Guimi No.2’ plant grown in the kiwifruit germplasm resource garden of Guizhou, China. A modified…
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Emerging trends in prime editing for precision genome editing
Kim, H. & Kim, J. S. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet. 15, 321–334 (2014).
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Wang, J. Y. & Doudna, J. A. CRISPR technology: a…
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Whole genome sequence of petroleum hydrocarbon degrading novel strain Microbacter sp. EMBS2025 isolated from Chilika Lake, Odisha, India
Microbial characterization and biosurfactant production
In our previous study, a microbial consortium was isolated from an oil-contaminated sample collected from Chilika Lake. The isolates were cultured on basal media under three distinct…
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Prior learning governs human experience-based risk-taking
Variability in human risk-taking in decisions involving potential gains or losses can be explained by the relative subjective value (or weight) assigned to each outcome. In a new study, Erdman et al. reveal that prior experience, rather than…
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
Inhibitor-bound MKP5-CD crystal structures exhibit conformational changes in both the allosteric and catalytic pockets
In our previous study using high-throughput screening, we identified compound 1 (Cmpd 1) as an inhibitor of MKP5 catalytic…
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Rethinking life through digital evolution
What is life?
This fundamental question has long been debated, and a universally accepted definition of a living system remains ambiguous. Some definitions emphasize metabolism, whereas others focus on reproduction, complexity or homeostasis, yet…
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A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Gliomas harbor a diverse landscape of alterations in FGFR family members and are associated with specific patterns of age and co-mutations
FGFR alterations in pediatric gliomas have been described; however, their incidence and association with tumor…
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A framework for complex signal processing via synthetic biological operational amplifiers
Decomposing multidimensional signals by synthetic orthogonal signal transformation circuits
Gene expression in biological systems is influenced by various environmental signals, such as nutrient availability, temperature, and stress. These signals…
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