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Category: 5. Biology
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In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression
This pilot in vitro study explored how decompression-induced microbubble nucleation and acoustic softening contribute to flow instability and potential SFC in human blood. The experimental setup simulated pressure conditions relevant to DCS,…
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A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides
Azaldegui, C. A., Vecchiarelli, A. G. & Biteen, J. S. The emergence of phase separation as an organizing principle in bacteria. Biophys. J. 120, 1123–1138 (2021).
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Melting KRAS resistance | Nature Chemical Biology
Hofmann, M. H., Gerlach, D., Misale, S., Petronczki, M. & Kraut, N. Cancer Discov. 12, 924–937 (2022).
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Zhao, Z., Mei, Y., Wang, Z. & He, W. Cancers…
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CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
Ethics statement
Our research complies with all relevant ethical regulations of Fudan University. All animal experiments were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee of Fudan University…
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Miniaturized scalable arrayed CRISPR screening in primary cells enables discovery at the single donor resolution
Primary human skeletal muscle myoblast culturing
Primary human skeletal muscle myoblasts from a male, non-smoking donor was obtained from Zen-Bio and cultured according to protocols provided by the vendor. Briefly, cells were cultured at 37 °C,…
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In-cell NMR reveals the first direct observation of endogenous interaction between HIV Tat protein and Tat RNA aptamer in human cells
Cell culture and expression of HIV Tat protein in HeLa cells
HeLa cells (ATCC® CCL-2™), a human cervical epithelial carcinoma cell line, were grown in high-glucose Dulbecco’s Modified Eagle Medium (DMEM) containing 10% heat-inactivated fetal…
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Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation
CLL transcriptome data
For all considered CLL datasets (Table S3, refs. 38,39,40), we first performed gene expression filtering using statistical distribution fitting and threshold-based filtering (Fig. S1, Methods)14,41. From the whole…
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Frozen in Time: The Hidden Trick That Keeps Human Eggs Alive for Decades
Human eggs can remain viable for decades by dialing down their internal recycling systems, new research shows. Studying over 100 freshly donated eggs, scientists discovered that slowing protein breakdown helps minimize harmful byproducts that…
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Three orphaned groundhogs released back into the wild
Three rescued groundhog (Marmota monax) siblings were joyfully released back…
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