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Category: 5. Biology
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Retrospective study of onychomycosis patients treated with ciclopirox 8% HPCH and oral antifungals applying artificial intelligence to electronic health records
The present study provides real-world evidence of the management of patients diagnosed with onychomycosis in daily practice conditions. A key finding of the study was that treatment combinations of CPX 8% HPCH with terbinafine, itraconazole, and…
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Collagen IV in Gould syndrome and Alport syndrome
Fidler, A. L. et al. Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues. Elife 6, e24176 (2017).
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Fidler, A. L., Boudko, S. P.,…
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Computational design of bifaceted protein nanomaterials
Docking
From the PDB file containing CrownC5-1, which had its five-fold rotational symmetry axis aligned to the z axis, we removed all but three chains of one ABC heterotrimer and truncated the C component by 1–4 helices. Because RPXdock is…
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Deep, long-read metagenome sequencing expands knowledge of prokaryotic phylogenetic diversity
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This is a summary of: Sereika, M. et al. Genome-resolved long-read sequencing expands known microbial…
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Revolutionizing CRISPR technology with artificial intelligence
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Porteus, M. H. &…
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Revolution of Biotechnology with CRISPR
CRISPR–Cas9 has been widely used to study fundamental biological processes, including DNA metabolism, development, physiology and pathology. Cheng et al. review how CRISPR–Cas9 has been utilized as a genome modification tool to introduce…
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A chromosome-level genome assembly of Guimi No. 2 (Actinidia chinensis)
Materials collection and sequencing
Fresh young leaves used for genome sequencing were collected from the A. chinensis var. chinensis ‘Guimi No.2’ plant grown in the kiwifruit germplasm resource garden of Guizhou, China. A modified…
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Emerging trends in prime editing for precision genome editing
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Wang, J. Y. & Doudna, J. A. CRISPR technology: a…
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