Addgene, a purpose-driven organization helping scientists conduct experiments with greater ease, speed, and reproducibility, today announced a strategic partnership with Promega to expand Addgene’s vast plasmid repository with…
Category: 5. Biology
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Deep, long-read metagenome sequencing expands knowledge of prokaryotic phylogenetic diversity
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This is a summary of: Sereika, M. et al. Genome-resolved long-read sequencing expands known microbial…
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Revolutionizing CRISPR technology with artificial intelligence
Bibikova, M., Beumer, K., Trautman, J. K. & Carroll, D. Enhancing gene targeting with designed zinc finger nucleases. Science 300, 764–764 (2003).
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Porteus, M. H. &…
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Revolution of Biotechnology with CRISPR
CRISPR–Cas9 has been widely used to study fundamental biological processes, including DNA metabolism, development, physiology and pathology. Cheng et al. review how CRISPR–Cas9 has been utilized as a genome modification tool to introduce…
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A chromosome-level genome assembly of Guimi No. 2 (Actinidia chinensis)
Materials collection and sequencing
Fresh young leaves used for genome sequencing were collected from the A. chinensis var. chinensis ‘Guimi No.2’ plant grown in the kiwifruit germplasm resource garden of Guizhou, China. A modified…
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Emerging trends in prime editing for precision genome editing
Kim, H. & Kim, J. S. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet. 15, 321–334 (2014).
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Wang, J. Y. & Doudna, J. A. CRISPR technology: a…
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Whole genome sequence of petroleum hydrocarbon degrading novel strain Microbacter sp. EMBS2025 isolated from Chilika Lake, Odisha, India
Microbial characterization and biosurfactant production
In our previous study, a microbial consortium was isolated from an oil-contaminated sample collected from Chilika Lake. The isolates were cultured on basal media under three distinct…
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Prior learning governs human experience-based risk-taking
Variability in human risk-taking in decisions involving potential gains or losses can be explained by the relative subjective value (or weight) assigned to each outcome. In a new study, Erdman et al. reveal that prior experience, rather than…
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
Inhibitor-bound MKP5-CD crystal structures exhibit conformational changes in both the allosteric and catalytic pockets
In our previous study using high-throughput screening, we identified compound 1 (Cmpd 1) as an inhibitor of MKP5 catalytic…
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