A phylogenomic tree of strepsirrhines
Using a phylogenomic dataset comprising 334 nuclear loci with an average length of 3339 base pairs (bp; range: 158–6985 bp; total concatenated alignment length: 1,108,850 bp), we reconstructed a…
Category: 5. Biology
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Redox mechanism of glycerophospholipids and relevant targeted therapy in ferroptosis
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.
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Li X, He J, Gao X,…
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The number of immune defence and counter-defence systems sustained in the arms race between prokaryotes and viruses
Population dynamics
Consider a community populated by strains of cells and viruses, distinct only in the repertoires of their defence and counter-defence systems. The community is well-mixed and has no spatial structure, so at each time point its…
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G-quadruplexes define promoter identity in mammals
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This is a summary of: Esnault, C. et al. G-quadruplexes are promoter elements controlling nucleosome…
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Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks
Santos Correa, S., Schultz, J., Lauersen, K. J. & Soares Rosado, A. Natural carbon fixation and advances in synthetic engineering for redesigning and creating new fixation pathways. J. Adv. Res. 47, 75–92 (2023).
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Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia
All experimental procedures were conducted in accordance with relevant ethical regulations and approved by the appropriate institutional review boards or ethics committees.
Human subjects
All human samples (healthy individuals and CF patients) were…
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Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget
For details, please refer to Methods S1–S3 in the supplementary materials.
Determination method of apparent longevity (AL) (refer to Supplementary Method S1)
Mathematical model
The following mathematical model1 can estimate AL from the number of…
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Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism
Saint-Criq, V. & Gray, M. A. Role of CFTR in epithelial physiology. Cell. Mol. Life Sci. 74, 93–115 (2017).
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Cheng, S. H. et al. Phosphorylation of the R domain by cAMP-dependent…
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The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis
Study design
We conducted the initial quantification of leukocyte and macrophage infiltration in the skeletal muscle of control individuals and ALS patients. We excluded muscle samples from clinically slow-progressing patients. We then assessed…
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Modulation of oral vaccine efficacy by the gut microbiota
Vaccination has eradicated or nearly eradicated smallpox and polio, reduced the severity of many diseases, and can prevent the development of cancers, such as cervical cancer1. Since the beginning of the coronavirus disease 2019 (COVID-19)…
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