Neutrophils are traditionally recognized for their pro-inflammatory roles. However, accumulating evidence has begun to highlight the plasticity of transcriptional states of neutrophils during…
Category: 5. Biology
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Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies
Human specimens
The human PBMC sample used in this study was obtained under the study, VRC 200, a protocol for apheresis and specimen collection procedures to obtain plasma, PBMCs and other specimens for research studies (ClinicalTrials.gov…
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2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Animal care and breeding
All mice analysed in this study were bred and housed at the CECAD Research Center animal facility, University of Cologne. All experiments were conducted in compliance with National Institutes of Health guidelines and…
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Digital twins and Big AI: the future of truly individualised healthcare
Foundational Research Gaps and Future Directions for Digital Twins | National Academies. https://www.nationalacademies.org/our-work/foundational-research-gaps-and-future-directions-for-digital-twins.
Coveney, P. V. & Highfield R. Virtual You: How…
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The second messenger c-di-AMP controls natural competence via ComFB signaling protein
Natural competence requires a contractile pilus system. Here, we provide evidence that the pilus biogenesis and natural competence in cyanobacteria are regulated by the second messenger c-di-AMP….
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Phosphorylation powers plant Polycomb | Nature Plants
Lewis, P. H. Melanogaster – new mutants: report of Pamela H. Lewis. Dros. Inform. Serv. 21, 69 (1947).
Muller, J. et al. Cell 111, 197–208 (2002).
…
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Nde1 promotes Lis1 binding to full-length autoinhibited human dynein 1
Reck-Peterson, S. L., Redwine, W. B., Vale, R. D. & Carter, A. P. The cytoplasmic dynein transport machinery and its many cargoes. Nat. Rev. Mol. Cell Biol. 19, 382–398 (2018).
McNally, F. J….
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Presence of high-risk nano particulate matters in powder injection: microscopic evaluation and investigation of particles contamination
The presence of particulate matter in parenteral or injectable medicines remains a significant concern for both manufacturers and consumers. Media outlets frequently report on product recalls due to particle contamination. The most common types…
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Contribution of displacement, duration, and velocity on auditory motion direction perception in macaque monkeys
Psychophysical performance
First, we analyzed psychometric performance for each monkey on the motion direction task to compare their performance across conditions with the same duration, displacement, and velocity as exemplified in Fig. 1C. These…
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Comparative metagenomics on community structure and diversity of rhizomicrobiome associated with monoculture and soybean precedent carrot
Shotgun metagenomics approach was employed in this study to provide insight into how cropping systems affect the diversity and community structure of the core microbiomes associated with the carrot rhizosphere. The study compared the abundance…
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