Category: 5. Biology

  • Salk Institute’s ShortStop revolutionizes genetic search

    Salk Institute’s ShortStop revolutionizes genetic search

    Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins called…

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  • Researchers uncover PSAT1 gene as key to heart repair post-heart attack

    Researchers uncover PSAT1 gene as key to heart repair post-heart attack

    Heart attacks remain a leading cause of death and disability worldwide. The permanent loss of heart muscle cells-known as cardiomyocytes-and the heart’s limited regenerative capacity often led to chronic heart failure.

    Current…

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  • Study sheds light on molecular mechanisms of brain aging

    Study sheds light on molecular mechanisms of brain aging

    Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells – a process called “proteostasis,” or protein homeostasis. Brain cells in particular fall prey to proteostasis disruptions, which…

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  • Influence of ATG SNPs on hip fracture patients’ functional status

    The most important finding of this work is that it shows the existence of a relationship between some autophagy genes polymorphisms and the functional status of older patients presenting a hip fracture. Hip fracture in the older population…

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  • Bird sternum evolution facilitated the origins of powered flight

    Bird sternum evolution facilitated the origins of powered flight

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Lowi-Merri, T. M. et al. Enlargement of sternum traits facilitated the evolution of…

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  • Jones, R. C. et al. The Tabula sapiens: a multiple-organ, single-cell transcriptomic atlas of humans. Science 376, eabl4896 (2022).

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  • Strogatz, S. H. Nonlinear Dynamics and Chaos: With…

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  • IC2Bert: masked gene expression pretraining and supervised fine tuning for robust immune checkpoint blockade (ICB) response prediction

    IC2Bert: masked gene expression pretraining and supervised fine tuning for robust immune checkpoint blockade (ICB) response prediction

    Datasets

    We employed 13 immune checkpoint blockade (ICB) response cohorts derived from 11 published studies, encompassing a total of 1,214 patients (31.8% responders). Metastatic melanoma was the most frequently studied cancer type, while other…

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  • The molecular basis of lamin-specific chromatin interactions

    The molecular basis of lamin-specific chromatin interactions

    Statistics and reproducibility

    No statistical methods were used to predetermine sample size. No data were excluded from the analyses. The data met the assumptions of the statistical tests used; normality and equal variances were formally tested. The…

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