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Category: 5. Biology
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Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels
Functional impact of S4 helix LQTS mutations on hERG channel activation
To investigate how specific charged residues in the S4 helix contribute to voltage sensing and gating in hERG channels, we focused on a subset of mutations previously…
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Rare purple crabs spotted in Thailand
What’s purple, white, and hard all over? Some rare crabs, according to…
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Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions
Our goal is to develop and benchmark a method to “coerce” AlphaFold2 to predict multiple conformations of a protein that are consistent with an experimental data set. Therefore, we initially selected two transporters to test the hypothesis…
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Efficient temporary pollen storage techniques for quality kiwifruit production
Using in vitro germination and acetocarmine tests, the germination of fresh pollen from two kiwifruit cultivars was investigated (Table 3). The results of both viability tests varied depending on the cultivar. The in vitro germination test…
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RNA sequencing and immunohistochemistry jointly improve tumor biomarker interpretation
Correlations between IHC and RNA-seq data of biomarkers in solid carcinomas
We first investigated mRNA expression distributions and correlations between levels of single genes measured by RNA-seq (Fig. 1A) and corresponding protein expression…
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High performance data integration for large-scale analyses of incomplete Omic profiles using Batch-Effect Reduction Trees (BERT)
Algorithm and Implementation
For data integration, BERT relies on the algorithms ComBat and limma, which both mandate that each batch exhibits at least two numerical values per feature. BERT relaxes this condition by additionally allowing features…
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Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study
Study population with transcriptomic or proteomic data
The level-3 TCGA-HNSCC gene expression data (including 44 paired tumor and adjacent tissues) were obtained from the University of California-Santa Cruz Xena browser (http://xena.ucsc.edu/),…
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New Release of User-Captured Images from the Oregon Health & Science University Melanoma MoleMapper Project
Smartphone applications
The MoleMapper application was designed for Apple iPhones using standard iOS frameworks to control the user interface and camera. The participant enrolment process used Apple’s ResearchKit framework and Sage…
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Author Correction: Impact of photobleaching on quantitative, spatio-temporal, super-resolution imaging of mitochondria in live C. elegans larvae
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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