Ethics statement
Ethical oversight for all human data described in this study was provided by Phoenix Children’s Hospital (Institutional Review Board no. 15-080), University College London Queen Square Institute of Neurology (22/NE/0080, project…
Category: 5. Biology
-
Author Correction: In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
Continue Reading
-
PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity
PROCR dampens the efficacy of radiotherapy in an immune-dependent manner
We previously found that PROCR could sustain tumour stemness by reprogramming lipid metabolism19. Given that both cancer stem cells and lipid metabolism are involved in…
Continue Reading
-
Synchronous surgery combined preoperative chemotherapy benefits patients suffering pancreatic ductal adenocarcinoma with liver metastases: a systematic review and meta-analysis
Siegel, R. L., Miller, K. D., Wagle, N. S. & Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin. 73, 17–48. https://doi.org/10.3322/caac.21763 (2023).
Google Scholar
Strobel, O.,…
Continue Reading
-
Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Marine natural compounds
Pacificusoside C, cucumariosides C1 and C2 were isolated from the sea star Solaster pacificus as previously described15. Specimens of S. pacificus were collected near Iturup Island (Sea of Okhotsk) by scuba diving in…
Continue Reading
-
Vibrio pectenicida strain FHCF-3 is a causative agent of sea star wasting disease
Eisenlord, M. E. et al. Ochre star mortality during the 2014 wasting disease epizootic: role of population size structure and temperature. Philos. Trans. R. Soc. B 371, 20150212 (2016).
Hewson,…
Continue Reading
-
The antibody-peptide fusion protein, AT-02, is an effective opsonin with pan-amyloid reactivity
Antibody production and purification
A humanized IgG1κ VH9/VL4 monoclonal antibody (mAb) was generated from the murine 11-1F4 antibody19,20,28,59 by homology modeling and backmutation (Genscript, NJ). Nucleotide sequences encoding a spacer and a…
Continue Reading
-
Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling
Production of Sloppymerase
To purify Sloppymerase, an overnight culture was created from BL21 E. coli (Thermo Fisher Scientific) that have been transformed by heat-shock with the Sloppymerase vector (VectorBuilder). The bacteria were inoculated…
Continue Reading
-
Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis
Transcriptomic profiling of tissue samples from skeletal muscle biopsies from patients with irMyositis versus patients with Mi2 and TIF1γ subtype
Table 3 summarizes the characteristics of 35 patient samples used in this study. The cohort consists…
Continue Reading
-
Neurons feed tumors | Nature Neuroscience
Nerves appear to promote the aggressiveness of nearby cancers, but the mechanisms underlying this effect are poorly understood. A study by Hoover and colleagues in Nature reveals that breast cancer cells metabolically rely on neurons. In the…
Continue Reading