T cell receptor sequencing reveals clonal expansion in the substantia nigra of Parkinson’s disease subjects
Previous studies in postmortem tissue have indicated that T cells are increased in the parenchyma of the substantia nigra (SN) of…
Category: 5. Biology
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Macrophages say NO to nucleotide synthesis and salvage instead
Macrophages say NO to nucleotide synthesis and salvage instead
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Infants’ neural processing of emotional faces after ostracism
Williams, K. D. & Ostracism Annu. Rev. Psychol. ;58: 425–452. doi:https://doi.org/10.1146/annurev.psych.58.110405.085641 (2007).
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Abrams, D., Weick, M., Thomas, D., Colbe, H. &…
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Space-driven ROS in cells: a hidden danger to astronaut health and food safety
Pandith, J. A., Neekhra, S., Ahmad, S. & Sheikh, R. A. Recent developments in space food for exploration missions: a review. Life Sci. Space Res. 36, 123–134 (2023).
Sugimoto, M. et al….
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Swapping microglia to treat ALSP
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a fatal neurological disease caused by mutations in the CSF1R gene. CSF1R is primarily expressed in microglia in the brain. In a recent study published in Science,…
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A programmed decline in ribosome levels governs human early neurodevelopment
Ethics statement
Ethical oversight for all human data described in this study was provided by Phoenix Children’s Hospital (Institutional Review Board no. 15-080), University College London Queen Square Institute of Neurology (22/NE/0080, project…
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Author Correction: In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity
PROCR dampens the efficacy of radiotherapy in an immune-dependent manner
We previously found that PROCR could sustain tumour stemness by reprogramming lipid metabolism19. Given that both cancer stem cells and lipid metabolism are involved in…
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Synchronous surgery combined preoperative chemotherapy benefits patients suffering pancreatic ductal adenocarcinoma with liver metastases: a systematic review and meta-analysis
Siegel, R. L., Miller, K. D., Wagle, N. S. & Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin. 73, 17–48. https://doi.org/10.3322/caac.21763 (2023).
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Strobel, O.,…
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Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Marine natural compounds
Pacificusoside C, cucumariosides C1 and C2 were isolated from the sea star Solaster pacificus as previously described15. Specimens of S. pacificus were collected near Iturup Island (Sea of Okhotsk) by scuba diving in…
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