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Category: 5. Biology
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P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions
Mice
Prex2–/– were previously described15, and were backcrossed 10 times to C57Bl6 genetic background, unless otherwise indicated. Prex2–/– mice were compared to Prex2+/+ mice derived on the same genetic background. To minimise genetic…
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Genome-wide association mapping and transcriptional analysis uncover genetic determinants of minor tocopherols in rice seeds
Vitamin E contents in germplasm of rice grains
The total grain tocopherol content was quantified in 179 rice accessions via HPLC against standards of vitamin E isomers (δ, γ). The retention time was 10–15 min (Supplementary Figure S2). The…
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Ribogenesis shaping the brain | Nature Cell Biology
Ozkan, A. et al. in Patterning and Cell Type Specification in the Developing CNS and PNS 2nd edn (eds Rubenstein, J. et al.) 427–459 (Elsevier, 2020).
Zhou, Y., Song, H. & Ming, G. Nat. Rev. Genet. 25, 26–45 (2024).
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Cancer stem cells: landscape, challenges and emerging therapeutic innovations
Yu, X. et al. CD133, stem cells, and cancer stem cells: Myth or reality? Curr. Colorectal Cancer Rep. 7, 253–259 (2011).
Kim, W. T. & Ryu, C. J. Cancer stem cell surface markers on normal…
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Intracrine FFA4 signaling controls lipolysis at lipid droplets
FFA4 signals through Gi/o on HEK293 intracellular membranes
Whereas FFA4 was originally thought to be primarily coupled to Gq/11 (refs. 12,13), recent studies in undifferentiated cells have additionally revealed Gi/o coupling11,14,15, which could…
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Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer
Chow, L. Q. M. Head and neck cancer. N. Engl. J. Med. 382, 60–72 (2020).
Johnson, D. E. et al. Head and neck squamous cell carcinoma. Nat. Rev. Dis. Primers 6, 92 (2020).
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Anatomical and histological analysis of an undescribed cervical skin fold structure in spotted turtles (Clemmys gutatta)
Gross examination
The cervical structure has a significantly different color, texture, and scale size compared to the adjacent skin of the neck (Figs. 2 and 3). The adjacent skin appears to have a thin texture with smaller scales, and a darker…
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Molecular mechanisms of cryoablation-mediated lung cancer suppression unveiled by non-coding RNA regulatory network profiling
Cryoablation suppresses LLC tumor growth in mice
The experimental design is illustrated in Fig. 1A, where LLC tumor mice were divided into 3 groups: model, cryoablation, and DDP. Cryoablation was performed using the argon-helium cryosurgical…
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In vivo engineering broadens CAR-T cell therapy use
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