A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome…
Category: 5. Biology
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From Spheroids to Insights: The Game-Changing Power of Incucyte® CX3
An interview with Lindy O’Clair, Head of Incucyte® Product Management at Sartorius
3D cell models like spheroids and organoids are transforming the way we study complex biological processes—but they…
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New insights into how genes influence frailty in older adults
A new study has identified genetic variants linked to brain function, immune defense and metabolism that contribute to the development of frailty in older people. The study, published in Nature Aging by researchers from Karolinska…
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Subtle genetic shifts in brain enzyme offer clues to human evolution
The evolutionary success of our species may have hinged on minute changes to our brain biochemistry after we diverged from the lineage leading to Neanderthals and Denisovans about half a million years ago.
Two of these tiny…
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LptM protein revealed as essential to outer membrane stability in bacteria
Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria. Their formidable defensive capabilities stem from their outer membrane (OM),…
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New insights reveal how sugar metabolism protects neurons from degeneration
Unlike most cells in the human body, neurons-the functional cells of our nervous system-cannot typically replace themselves with healthy copies after being damaged.
Rather, after an injury from something like a stroke, concussion…
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Intracrine FFA4 signaling controls lipolysis at lipid droplets
FFA4 signals through Gi/o on HEK293 intracellular membranes
Whereas FFA4 was originally thought to be primarily coupled to Gq/11 (refs. 12,13), recent studies in undifferentiated cells have additionally revealed Gi/o coupling11,14,15, which could…
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Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer
Chow, L. Q. M. Head and neck cancer. N. Engl. J. Med. 382, 60–72 (2020).
Johnson, D. E. et al. Head and neck squamous cell carcinoma. Nat. Rev. Dis. Primers 6, 92 (2020).
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Anatomical and histological analysis of an undescribed cervical skin fold structure in spotted turtles (Clemmys gutatta)
Gross examination
The cervical structure has a significantly different color, texture, and scale size compared to the adjacent skin of the neck (Figs. 2 and 3). The adjacent skin appears to have a thin texture with smaller scales, and a darker…
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Molecular mechanisms of cryoablation-mediated lung cancer suppression unveiled by non-coding RNA regulatory network profiling
Cryoablation suppresses LLC tumor growth in mice
The experimental design is illustrated in Fig. 1A, where LLC tumor mice were divided into 3 groups: model, cryoablation, and DDP. Cryoablation was performed using the argon-helium cryosurgical…
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