Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators have defined a new genetic disease marked by premature aging and deficits in brain function.
The researchers published…
Category: 5. Biology
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Breakthrough research reshapes understanding of T cell immune responses
In a paradigm breaking study, Dr. Pavan Reddy, director of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine (BCM) and his team, in collaboration with Drs. Arul Chinnaiyan, S P Hicks Endowed Professor of…
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Two Species of Marsupials Thought Lost for 6,000 Years Found Alive in New Guinea
In the remote rainforests of New Guinea’s Vogelkop Peninsula, scientists have spotted two marsupial species — the pygmy long-fingered possum (Dactylonax kambuayai) and the ring-tailed glider (Tous ayamaruensis) — believed to have been…
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Functional m6A site detection by FOCAS
The RNA modification N6-methyladenosine (m6A) of eukaryotic mRNAs has emerged as a central regulator of cancer progression. However, determining which RNA modification sites have functional relevance in cancer has proven difficult. Traditional…
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GPR109a-AMPK axis mediates the Attenuation of uric acid-induced M1 macrophage polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b
Li, L., Zhang, Y. & Zeng, C. Update on the epidemiology, genetics, and therapeutic options of hyperuricemia. Am. J. Transl Res. 12, 3167–3181 (2020).
Hu, H. et al. The SGLT2 inhibitor…
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Who let the wolves in? Genetic record for domestic dogs pushed back by 5,000 years
Dogs (Canis lupus familiaris) were domesticated from grey wolves (Canis lupus) at least 14,200 years ago, towards the end of the last ice age.Credit: Martin Schroeder/CHROMORANGE via Alamy
Dogs were early man’s best friend. A pair of Nature…
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Cortex-wide characterization of decision-making neural dynamics during spatial navigation
Harvey, C. D., Coen, P. & Tank, D. W. Choice-specific sequences in parietal cortex during a virtual-navigation decision task. Nature 484, 62–68 (2012).
Gilad, A., Gallero-Salas, Y., Groos, D….
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TPTE, a testis-specific PTEN family member, drives spermatogenesis via PI(4,5)P2 synthesis
Kubota H, Brinster RL. Spermatogonial stem cells. Biol Reprod. 2018;99:52–74.
Walker WH. Regulation of mammalian spermatogenesis by miRNAs. Semin Cell Dev Biol. 2022;121:24–31.
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Rhizobacteria opportunistically boost colonization and impair plant fitness by degrading plant-derived coumarins under iron deficiency
Wang, S., Alseekh, S., Fernie, A. R. & Luo, J. The structure and function of major plant metabolite modifications. Mol. Plant 12, 899–919 (2019).
Fang, C., Fernie, A. R. & Luo, J. Exploring…
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Access to β-acetoxyselenides, perhydroindolones and anticancer piperidinones via blue LED-driven selenylation of unsaturated carboxamides
Ferdousian, R. & Behbahani, F. K. Organoselenium compounds. synthesis, application, and biological activity. Phosphorus Sulfur Silicon Relat. Elem. 197, 1179–1212 (2022).
Saeed, S. et al….
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