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Lee, J. Y., Keane, M. G. & Pereira, S. Diagnosis and treatment of gallstone disease….
Category: 5. Biology
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(R)-WAC-224, a new anticancer quinolone, combined with venetoclax and azacitidine overcomes venetoclax-resistant AML through MCL-1 downregulation
Reagents
5-methyl-7-[3-({[(2R)-oxan-2-yl]methyl}carbamoyl)azetidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid [(R)-WAC-224 (R-WAC)], was synthesized by Wakunaga Pharmaceutical (Hiroshima, Japan, Fig. 1)….
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Structural and functional insights into the nuclear role of Parkinson’s disease-associated α-synuclein as a histone chaperone
αSyn forms complex with both H2a-H2b dimer and (H3-H4)
2
tetramer
αSyn belongs to the intrinsically disordered protein (IDP) family composed of 140 amino acids…
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Simulating mismatch between calibration and target population in AI for mammography the retrospective VAIB study
Study population
A total of 7790 exams from 6028 cancer-diagnosed participants and 38,509 exams from 27,422 healthy participants were included in the final case-control dataset. The cohort data had a total of 867 exams from 864 cancer-diagnosed…
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Analysis of biofilm assembly by large area automated AFM
High-resolution AFM imaging of Pantoea sp. YR343
In this study, we focus on Pantoea sp. YR343, a gram-negative bacterium isolated from the poplar rhizosphere, is known for its plant-growth-promoting properties. Pantoea sp. YR343 is a rod-shaped,…
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Unveiling the role of Ndrg1 gene on the oxidative stress induction behind the anticancer potential of styrylquinazoline derivatives
Activity landscape of IS20 against cell lines with different TP53 status
Understanding the molecular mechanism of action of the 2-styrylquinazoline derivative IS20 began by evaluating its antiproliferative profile on five GBM cell lines, including…
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FXR protects against neonatal sepsis by enhancing the immunosuppressive function of MDSCs
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801–10. https://doi.org/10.1001/jama.2016.0287.
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A nuclear-encoded endonuclease governs the paternal transmission of mitochondria in Cucumis plants
Zhao, Y. N. et al. Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana. Cell Res. 28, 448–461 (2018).
…
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Assessment of ghrelin serum level and gene polymorphism as a risk factor in progression of chronic viral hepatitis
Liver disease represents a significant health challenge in Egypt, contributing to high mortality rates and an extensive medical and economic burden2. Although the prevalence of chronic viral hepatitis has declined following a nationwide control…
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Author Correction: In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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