Category: 5. Biology

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  • Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology

    Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology

    Ethics

    Regarding the participant sample, the study was approved by the Scientific Committee of the tumor bank of Lille and the Department of Pathology in Lille University Hospital. The participant signed an informed consent form.

    Maintenance of…

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  • Correction: Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis

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  • Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells

    Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells

    The fetal bone marrow does not support terminal hematopoiesis and grows by recruitment of mature myeloid cells

    Recent studies in adult mice have shown that bone marrow hematopoiesis has a unique spatial anatomy. This is characterized by an even…

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  • Tumor break load quantitates structural variant-associated genomic instability with biological and clinical relevance across cancers

    Tumor break load quantitates structural variant-associated genomic instability with biological and clinical relevance across cancers

    Datasets and genomic instability metrics

    To assess the clinical and biological implications of TBL in relation to other measures of genomic instability across various cancers, public data from two primary pan-cancer datasets with genomics,…

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  • Aging and injury drive neuronal senescence in the dorsal root ganglia

    Aging and injury drive neuronal senescence in the dorsal root ganglia

    Animals

    All animal procedures were approved by the Stanford University Administrative Panel on Laboratory Animal Care and the Institutional Animal Care and Use Committee (IACUC; 34760) in accordance with American Veterinary Medical Association…

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  • A multi-layered defense against adversarial attacks in brain tumor classification using ensemble adversarial training and feature squeezing

    A multi-layered defense against adversarial attacks in brain tumor classification using ensemble adversarial training and feature squeezing

    Dataset preparation

    We employed a composite dataset41 sourced from Kaggle, combining three datasets: Figshare42, SARTAJ43, and Br35H44. This collection includes 7,023 MRI brain images, categorized into four classes: glioma, meningioma, pituitary…

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  • Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein

    Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein

    CESLR2 expression is significantly higher on CD4 effector memory T cells in PD participants responding to α-syn compared to healthy controls

    Previous studies showed that α-syn T cell reactivity is associated with PD13, and that this inflammatory…

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