Category: 5. Biology

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  • Insights into the degradation mechanism of GID4-based proteolysis-targeting chimeras

    Insights into the degradation mechanism of GID4-based proteolysis-targeting chimeras

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    This is a summary of: Li, Y. et al. Design of PROTACs utilizing the E3 ligase GID4 for targeted protein…

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  • Building a unified model for drug synergy analysis powered by large language models

    Building a unified model for drug synergy analysis powered by large language models

    Problem definition

    In this manuscript, we intend to construct a dataset \({{\mathcal{D}}}=(X,Y)\) and pre-train a model known as \({{\mathcal{M}}}\) for the prediction of values in Yn×t, where n represents the number of combinations between drug…

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  • Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability

    Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability

    Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability

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