Frank, B., Glikman, J. A. & Marchini, S. Human–Wildlife Interactions: Turning Conflict into Coexistence – Google Books. Cambridge University Press vol. 23 (2019).
Nyhus, P. J. Human-Wildlife conflict and coexistence. Annu. Rev. Environ. Resour.…
Category: 5. Biology
-
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017).
Google Scholar
Karlsson, M. et al. A single-cell type transcriptomics map of human tissues. Sci. Adv. 7,…
Continue Reading
-
Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P2 binding
Reagents and plasmids
AVP and isoproterenol (ISO) were purchased from Sigma-Aldrich. Tetramethylrhodamine (TMR)-labeled HiBiT peptide (TMR–HiBiT: TMR-VSGWRLFKKIS) was synthesized in Genscript. SaraFluor650-labeled Flag–HiBiT23 (SF650–FiBiT:…
Continue Reading
-
Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase
Domain closure of D2HDH on substrate binding
The structure of the non-productive ternary complex of D2HDH with both oxidised NADP+ and 2-ketohexanoic acid was determined at 1.26 Å resolution, using crystals grown from protein prepared in 1 M…
Continue Reading
-
Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer
In silico analysis to identify new CD36 inhibitors
To identify new CD36 inhibitors, we screened in silico a commercial library of 30,000 compounds (https://www.hit2lead.com) targeting a protein region around the FA binding site centered at Val142…
Continue Reading
-
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
Human tissue samples
De-identified human specimens were collected from the Autopsy Service in the Department of Pathology at the University of California San Francisco (UCSF) (Supplementary Table 2) with previous patient consent in strict…
Continue Reading
-
HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoprotein
High-throughput LD phenotypic screen identifies HSP90 as an LD regulatory factor
The search for new regulatory factors in lipid metabolism has led us to establish an LD phenotypic screen on a small molecule compound library. In this screen, we…
Continue Reading
-
Mitochondrial subtypes in renal ischemia reperfusion injury guide delayed graft function and Long-Term graft prediction
Identification of DE-MGs and functional enrichment analysis
Differential expression analysis was conducted on 203 IRI samples and 188 control samples from the GSE43974 dataset. This analysis identified 103 DEGs, all of which exhibited significant…
Continue Reading
-
Enzymatic craftsmanship in collagen glycosylation
The coordinated activity of LH and GLT25D enzymes is essential for the synthesis and native folding of collagen proteins. Two independent studies by Qin, Cao, and coworkers4, and Forneris and coworkers5, have highlighted the formation of an…
Continue Reading
-
Cystobactamid off-target profiling reveals favorable safety, superoxide reduction, and SCARB1 inhibition in eukaryotes
CYS demonstrates general safety in cytotoxicity and genotoxicity assays, with a mild effect on uncoupling the mitochondrial electron transfer chain (ETC)
Three CYS derivatives (CN-861-2, CN-DM-861 and Cysto-180; Fig. 1a) were chosen to further…
Continue Reading