Chemsex is a practice that sits at the intersection of substance use and sexuality, which is predominantly reported by men who have sex with men. Understanding the sociodynamics of chemsex is important for developing public health…
Category: 5. Biology
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Chromosome fusions shaped karyotype evolution and evolutionary relationships in the model family Brassicaceae
Ancestral karyotype of supertribes Camelinodae and Brassicodae (ACBK)
We followed the workflow of WGDI toolkit25 (https://github.com/SunPengChuan/wgdi-example/blob/main/Karyotype_Evolution.md) to reconstruct ancestral karyotypes of Camelinodae and…
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Targeted pancreatic cancer therapy using 4-farnesyloxycoumarin conjugated nanocrystalline cellulose and Chitosan nanoparticles
This study aimed to assess the effects of 4-FOC-conjugated NCC/CTAB/CS NPs on PANC-1 cells, explicitly evaluating their cytotoxicity and antioxidant capacity.
DLS assay
The DLS analysis of 4-FOC-conjugated NCC/CTAB/CS NPs revealed key…
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VDAC2 enforces a mitochondrial checkpoint to cancer immunity
VDAC2 enforces a mitochondrial checkpoint to cancer immunity
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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
All research complies with relevant ethical regulations of the University of Veterinary Medicine Vienna. Fresh-frozen samples of primary bone-marrow mononuclear cells (MNCs) were obtained from the biobank of the St. Anna Children’s Hospital…
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Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment
Cell culture
Human cell lines (SUM-159PT, MRC5, MDA-MB-231) were cultured in DMEM High Glucose Medium (Thermo Fisher; cat. 41966-029) supplemented with 10% FBS (Thermo Fisher; cat. 10270-106) and 100 units/ml penicillin and 100 mg/ml…
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Testosterone affects the vaginal microbiome in transgender men
Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencing sexual health outcomes, specifically the occurrence of bacterial vaginosis.
In this prospective longitudinal study,…
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Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS
Antibodies
Custom mouse monoclonal antibodies against the FUS C-termini were generated at Boster Bio (Pleasanton, CA, USA) with antigens of wild-type P525 (n-DSRGEHRQDRRERPY-c; clone P3-A6C4) or mutant P525L (n-CGKMDSRGEHRQDRRERLY-c; clone…
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Author Correction: Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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SLAM-RT&Tag: spatiotemporal profiling of RNA within nuclear compartments in situ
Nuclear compartments are non-membrane-bound regions enriched in functionally related molecules that coordinate biochemical reactions in space and time. Many compartments have important roles in RNA maturation, positioning them as crucial…
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