JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis
Category: 5. Biology
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JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis
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Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining
Network training
To train the network, we prepared the paired training dataset from a 4 μm-thick, H&E-stained colon cancer tissue slide (Fig. 2a). Initially, we utilized holotomography to capture both the 3D RI images and 2D single-channel BF…
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From field to analysis: strengthening reproducibility and confirmation in research for sustainable agriculture
Ioannidis, J. P. A. Why most published research findings are false. PLOS Med. 2, e124 (2005).
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Baker, M. 1500 scientists lift the lid on reproducibility. Nature 533, 452–454…
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A crossroads in the timeline of human evolution
Ancient DNA (aDNA) sequencing is like unlocking a genetic time capsule, almost bringing the past back to life and offering direct insights into the evolutionary processes that have shaped the living world. Yet, accessing DNA from ancient remains…
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Fattening the cycle | Nature Chemical Biology
Nicotinamide adenine dinucleotide phosphate (NADPH) is a reducing cofactor present in cytosolic and mitochondrial pools, with each pool requiring distinct NAD+ kinases (NADK and NADK2). NADK2 mediates production of mitochondrial NADP(H) and is…
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A task-invariant prior explains trial-by-trial active avoidance behaviour across gain and loss tasks
The research plan for this study was preregistered before the start of the data collection on 2024-01-09 at OSF: https://osf.io/rej74.
Participants
Three hundred sixty-eight participants between 18 and 40 years old were recruited in a sex…
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Restoring cellular energy | Nature Chemical Biology
Mitochondria serve as the energy factories of cells, powering various biological processes, and their dysfunction is linked to many types of disease, such as cancer, neurodegenerative diseases and metabolic disorders. For example, mutations in…
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Glioma-neuronal circuit remodeling induces regional immunosuppression
Study approval
For all human tissue studies, written informed consent was obtained from all patients, and tissue samples were used in accordance with the University of California, San Francisco (UCSF) institutional review board (IRB) for human…
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Making 3′ ends meet | Nature Structural & Molecular Biology
Otarbayev, D. & Myung, K. DNA Repair (Amst) 140, 103696 (2024).
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Zahn, K. E., Averill, A. M., Aller, P., Wood, R. D. & Doublie, S. Nat. Struct. Mol. Biol.…
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