Matsui, M. & Corey, D. R. Non-coding RNAs as drug targets. Nat Rev Drug Discov 16, 167–179 (2017).
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Hombach, S. & Kretz, M. Non-coding RNAs:…
Category: 5. Biology
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Mimicking the structure and function of tau folds associated with disease
Mimicking the structure and function of tau folds associated with disease
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Correction: Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future
Correction: Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future
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Author Correction: Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Inheriting traits | Nature Reviews Microbiology
Bacterial metabolic activity across generations has been shown to be unstable owing to stochastic gene expression and the environments of the bacteria. Previously, the inheritance of bacterial metabolic activity has often been investigated at the…
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Metagenomics distilled: new k-mer-based methods
k-mer-based methods have long been used for metagenomic analysis as they quickly and efficiently identify microorganisms in large datasets and enable the estimation of the relative abundance of microbial species and the tracking of strains in…
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Inhibition of Talin2 dedifferentiates myofibroblasts and reverses lung and kidney fibrosis
Study design
This study examines two related hypotheses. The first is that myofibroblast differentiation (from monocytes and fibroblasts) is governed by adhesion mechanics, and the second is that modulation of adhesion mechanics machinery can be…
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Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire
Study population and immune landscape annotation
PBMCs were obtained from 32 patients who underwent CD19-directed CAR T cell therapy in the registrational trial of axicabtagene ciloleucel (Axi-cel) (ZUMA-1/NCT02348216)2,3 (Supplementary Data 1,…
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Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement
Movement arrest, or the temporary cessation of movement, is a common and adaptive aspect of animal and human behavior1. It often occurs in response to unexpected events or the sudden appearance of obstacles that demand the immediate suppression…
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Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity
Animal work
All animal experiments were carried out in accordance with EU Directive 2010/63/EU (authorization from the Italian Ministry of Health: PR474/2021). The animals were maintained in a temperature- and humidity-controlled animal care…
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