Study design
This study examines two related hypotheses. The first is that myofibroblast differentiation (from monocytes and fibroblasts) is governed by adhesion mechanics, and the second is that modulation of adhesion mechanics machinery can be…
Category: 5. Biology
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Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire
Study population and immune landscape annotation
PBMCs were obtained from 32 patients who underwent CD19-directed CAR T cell therapy in the registrational trial of axicabtagene ciloleucel (Axi-cel) (ZUMA-1/NCT02348216)2,3 (Supplementary Data 1,…
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Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement
Movement arrest, or the temporary cessation of movement, is a common and adaptive aspect of animal and human behavior1. It often occurs in response to unexpected events or the sudden appearance of obstacles that demand the immediate suppression…
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Self-supervised learning from small-molecule mass spectrometry data
Bushuiev, R. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02663-3 (2025).
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M2 microglia-derived exosomes reduce neuronal ferroptosis via FUNDC1-mediated mitophagy by activating AMPK/ULK1 signaling
Jacquemyn, J., Ralhan, I. & Ioannou, M. S. Driving factors of neuronal ferroptosis. Trends Cell. Biol. 34 (7), 535–546. https://doi.org/10.1016/j.tcb.2024.01.010 (2024). Epub 2024/02/24. PubMed PMID: 38395733.
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Confronting the challenge of cell segmentation in spatial transcriptomics
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Jones, D. C. et al. Cell simulation as cell segmentation. Nat. Methods
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Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity
Ethical statement
All animal work was reviewed and approved by the LBNL Animal Welfare and Research Committee. All iPSC experiments were conducted following UCSF institutional guidelines. No commonly misidentified cell lines were used in the…
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Adjusting the scope of natural killer cells in cancer therapy
Sharma P, Goswami S, Raychaudhuri D, Siddiqui BA, Singh P, Nagarajan A, et al. Immune checkpoint therapy-current perspectives and future directions. Cell. 2023;186:1652–69.
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Correction: Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway
Correction: Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway
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Anthelmintic resistance against benzimidazoles and macrocyclic lactones in strongyle populations on cattle farms in northern Germany
Vercruysse, J. et al. Control of helminth ruminant infections by 2030. Parasitology 145, 1655–1664. https://doi.org/10.1017/s003118201700227x (2018).
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Fraser, D.,…
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