Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance, published in Developmental Cell, promises to…
Category: 5. Biology
-
Image guided construction of a common coordinate framework for spatial transcriptome data
Overview of the workflow of STaCker
STaCker is a deep learning algorithm designed to register a “moving” spatial transcriptome slice to a “reference” counterpart. In this work, we use the terms “reference”, “moving” and “moved”…
Continue Reading
-
KCNQ4 c.546C>G variant is associated with early-onset high-frequency hearing loss, tinnitus, and cardiovascular comorbidities in Taiwanese adults
This study demonstrates that the KCNQ4 c.546C>G variant is significantly associated with an increased risk of high-frequency sensorineural hearing loss, particularly at 8 kHz, and more severe tinnitus, as measured by the Tinnitus Handicap…
Continue Reading
-
Structure of AcMNPV nucleocapsid reveals DNA portal organization and packaging apparatus of circular dsDNA baculovirus
Structural determination of the native AcMNPV nucleocapsid
To determine the cryo-EM structure of the intact DNA translocation portal of AcMNPV, we extracted intact BVs by a single concentration step to the medium of our infected insect cells,…
Continue Reading
-
Bridging the gap between R and Python in bulk transcriptomic data analysis with InMoose
InMoose ports to Python prominent features from well-established R packages, to provide a single entry point for bulk transcriptomic data analysis. Our approach is to be as faithful to the original tools as possible, as demonstrated by our…
Continue Reading
-
Multiomic analysis of different horse breeds reveals that gut microbial butyrate enhances racehorse athletic performance
Horse recruitment
A total of 58 racehorses (Thoroughbred horse) were used in this study. These racehorses were bred in the same racecourse and trained under the same conditions for more than 4 months. They all followed the same daily training…
Continue Reading
-
Comprehensive curation and validation of genomic datasets for chestnut
Data collection
The CGD contains eight chestnut genomes, including seven from C. mollissima (‘HBY-2’6,7, ‘N11-1’8, ‘Sun’9, ‘Vanuxem’10, ‘drought-resistant’(H7)11, ‘early-maturing’(ZS)11 and ‘easy-pruning’(YH)11) and one…
Continue Reading
-
ATR-FTIR spectroscopic markers indicating drug resistance in selected Candida strains
Kainz, K., Bauer, M. A. & Madeo, F. Carmona-Gutierrez, D. Fungal infections in humans: The silent crisis. Microb. Cell. 7, 143–145 (2020).
Google Scholar
Continue Reading
-
Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs
Mice
Male and female WT (Charles River), CXCR2−/− (Jackson Lab, stock 006848), CXCR2fl/flCdh5Cre (Taconic stock 13073) and CXCR2fl/flShhCre mice (Jackson Lab, stock 005623) on a C57BL/6 background were kept in a specific pathogen-free/SPF…
Continue Reading
-
Innovative integration of biometric data and blockchain to enhance ownership and trust with NFTs
Our exploration of the convergence between biometric data and blockchain technology, culminating in the creation of Cell-NFTs, represents a transformative step in the digitalization of biological assets. The Cell-NFT model offers an innovative…
Continue Reading