Category: 5. Biology

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  • The estimated incidence of uterine corpus cancers among permanent residents in mainland China using Bayesian spatial modeling

    The estimated incidence of uterine corpus cancers among permanent residents in mainland China using Bayesian spatial modeling

    Cancer registries

    In 2016, data from 487 cancer registries in mainland China met the stringent quality control criteria. These registries cover 669 districts and counties, representing 28.6% of the total female household-registered resident. Among…

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  • Transcriptional reprogramming in oral squamous cell carcinoma

    Transcriptional reprogramming in oral squamous cell carcinoma

    In our study, we investigated potential biological targets for OSCC by analyzing four independent datasets. We employed integrated methodologies, including Robust Rank Aggregation (RRA) and Weighted Gene Co-expression Network Analysis (WGCNA), to…

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  • Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies

    Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies

  • Gaser, C., Kalc, P. & Cole, J. H. A perspective on brain-age estimation and its clinical promise. Nat. Comput. Sci. 4, 744–751 (2024).

  • Baecker, L., Garcia-Dias, R., Vieira, S., Scarpazza, C. & Mechelli, A. Machine learning for brain age…

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  • Silver nanoparticles derived from Streptomyces sp. YJD18 with multifunctional biomedical applications

    Silver nanoparticles derived from Streptomyces sp. YJD18 with multifunctional biomedical applications

    Preparation of microbiological cultures and cell-free supernatants monoclonal colonies of YJD18

    Soil samples were collected from the saline land around Wujiaqu City, Xinjiang Uygur Autonomous Region, and the collected soil samples were dried at…

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  • Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer

    Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer

    Cell lines and cell culture

    HCC827, PC9 and H1975 cells were cultured in RPMI-1640 media (21875-034, Gibco) supplemented with 10% fetal bovine serum (FBS) (10500-064, Gibco) and 1% Penicillin/Streptomycin (10.000 U/mL) (15140-122, Gibco). Cells…

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  • A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure

    A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure

    CFAX12 for in vitro analysis of cigarette smoke effects on-chip

    The Continuous Flow AX12 (CFAX12) exposure system was employed to investigate the effects of cigarette smoke on lung cells cultured in the AX12 Lung-on-chip (AlveoliX, Switzerland)…

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  • Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

    Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

    Cell lines and therapeutic agents

    Neat stocks of 1 × 109 TCID50 Rt3D were diluted 1:10 in DMEM for single-use aliquots and stored at −80 °C. Palbociclib was kindly provided by Pfizer.

    A375, Mel624, MeWo, A2058, Fadu, HN5 and Cal27 were…

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  • Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37

    Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37

  • Conduit, P. T., Wainman, A. & Raff, J. W. Centrosome function and assembly in animal cells. Nat. Rev. Mol. Cell Biol. 16, 611–624 (2015).

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  • Gould, R. R. &…

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