Tumor resident immune cells are preserved in both soft and stiff NC-gel cultured PDECs
To explore the effect of the mechanical microenvironment on TILs, patient-derived primary tumor tissue was processed into 3D PDECs as previously described12….
Category: 5. Biology
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Sotorasib resistance in KRAS G12C-mutant invasive mucinous adenocarcinoma with implications for VEGF-A
Pathological autopsy
Pathological autopsies were performed by the Pathology Department of Asahikawa Medical University Hospital. Following the cessation of vital functions, the postmortem interval at room temperature was 11 h and 53 min….
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Applying the theory of broken windows to microbiome studies
The study of the human microbiome has advanced considerably due to experimental and computational approaches, yet its clinical applications remain challenging due to the lack of standardised protocols…
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Genetically encoded fluorescent reporter for polyamines
Cloning and plasmid preparation
Complete plasmid sequences are provided in Supplementary Data 2. The sequence encoding the full-length human OAZ1 was obtained as double-stranded DNA fragments (IDT) and its various segments were cloned between…
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Food: Friend, Not Foe – New Study Explains Why – Life Sciences | Weizmann Wonder Wander
If we have an allergy to peanuts, strawberries or dairy, we are quick to blame our immune systems. But when we enjoy a diverse diet without any adverse reaction, we generally don’t realize that this is also the immune system’s doing. Our…
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Megalodon: The broad diet of the megatooth shark
Otodus megalodon was the largest predatory fish in Earth’s history: Measuring up to 24 meters, it was longer than a truck with a trailer and weighed almost twice as much. Embedded in its jaws were triangular teeth the size of a hand, and its bite…
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Flowers unfold with surprising precision, despite unruly genes
Flowers grow stems, leaves and petals in a perfect pattern again and again. A new Cornell study shows that even in this precise, patterned formation in plants, gene activity inside individual cells is far more chaotic than it appears from the…
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Ancient Psychoactive Plant Used in the Iron Ages
The recent discovery of Peganum harmala (Syrian rue) residues in Iron Age fumigation devices from the archaeological site of Qurayyah in Saudi Arabia offers a groundbreaking glimpse into ancient medicinal and…
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Urban rewilding has brought back beavers, hornbills and platypuses to city parks—and that’s just the start
Credit: Pixabay/CC0 Public Domain
By 2050, almost 70% of the world’s population will live in cities—20% more than today. As cities expand, the…
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The broad diet of the megatooth shark
The model of a megalodon can be seen in the Linz Castle Museum in Austria, for example. Credit: OÖ Landes-Kultur GmbH
Otodus megalodon was the…
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