Lyme disease is caused by Borrelia burgdorferi infection, which is transmitted via a tick vector. Lyme arthritis can be a postinfection, inflammatory complication of Lyme disease. Treatment with immunosuppressive agents is effective, which…
Category: 5. Biology
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NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance
Cell culture
All cell lines used in this study were sourced from the American Type Culture Collection (ATCC) and maintained under standardized conditions in a 5% CO2 incubator (Thermo Fisher Scientific) at 37 °C with humidified sterile water….
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An integrated approach using morphological, biochemical, and RAPD markers to assess the genetic diversity of Olive (Olea Europaea L.) cultivars in India
Morphological markers of the different Olive cultivars
The different cultivars showed variations in habit (canopy) of the olive tree and trunk pattern, as shown in Fig. 2. It is believed that evolution gave rise to the tree’s mechanically…
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Traditional Chinese herbal formulas modulate inflammatory mediators, antioxidant enzyme levels, and ruminal microbiota composition in postpartum female Yaks
Wen, Y. et al. Intestinal microbial diversity of free-range and captive Yak in Qinghai Province. Microorganisms 10, 754 (2022).
Google Scholar
Wiener,…
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Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
Purification of RNA polymerase II complexes in HeLa cell nuclei
The HeLa cell line expressing hexahistidine-FLAG-tagged RPB3 was established previously35, and tagged RPB3 expression was confirmed by western blot, using an anti-RPB3 antibody…
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Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism
Naïve behavior and associated neural activity patterns
Two NHPs were trained to acquire and reacquire their response to novel visual cues in a between-block design (Fig. 1b). First, they had to identify the spatial cue associated with the reward…
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BIT: Bayesian Identification of Transcriptional regulators from epigenomics-based query region sets
The integration of epigenomic profiling data has proven to be a feasible approach for identifying TRs in biomedical research24,35,36. It is well recognized that the binding sites of TRs critical to a specific biological process are primarily…
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De novo CDKN1C variant in Beckwith–Wiedermann spectrum with atypical complications
Beckwith–Wiedemann spectrum (BWSp) encompasses a range of clinical manifestations caused by genetic and epigenetic alterations at chromosome 11p15.5. Patients with a clinical diagnosis of…
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High-resolution imaging of RNA and proteins in thick tissues using cycleHCR
Competing interests
Z.J.L. is named as co-inventors on a patent application titled ‘Methods and compositions for imaging RNA and protein targets in biological specimens’, application number…
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Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma
Cell lines
D425 has been previously reported11 and was obtained from the Bigner Lab. D425 was cultured in Dulbecco’s Modified Eagle Medium (DMEM) (cat#11965092, Thermo Fisher Gibco, Waltham, MA) containing 10% fetal bovine serum (FBS)…
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