Method overview
scMODAL is a deep generative framework that learns integrated cell representations from single-cell multi-omics features. The input to scMODAL comprises cell-by-feature data matrices. For simplicity, we consider the scenario…
Category: 5. Biology
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Cross resistance emergence to polymyxins in Acinetobacter baumannii exposed in vitro to an antimicrobial peptide
In vitro selection of resistance towards TAT-RasGAP317-326 in A. baumannii recurrently results in cross-resistance to polymyxins
In order to study the potential of A. baumannii isolates to develop resistance to TAT-RasGAP317-326, we selected nine…
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Structural basis of GluK2 kainate receptor activation by a partial agonist
Hansen, K. B. et al. Structure, function, and pharmacology of glutamate receptor ion channels. Pharm. Rev. 73, 298–487 (2021).
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Lerma, J. Roles…
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Mycosynthesis of zinc oxide nanoparticles using Mucor racemosus with their antimicrobial, antibiofilm, anticancer and antioxidant activities
Salah, N. M., Saafan, A. E., Salem, E. H. & El Rabey, H. A. Inhibition of the Vancomycin resistance in Staphylococcus aureus in Egypt using silver nanoparticles. 2022, 7380147. (2022). https://doi.org/10.1155/2022/7380147
Hao, Y. et al. Advances…
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Intermittent control and retinal optic flow when maintaining a curvilinear path
Ethics
Informed consents were obtained from the research participants prior to the experiment to collect, process, and publish the research findings. The author depicted in Fig. 4 consented to the publication and use of the image. This research…
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In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents
Chemistry
The chalcones were synthesized by reacting substituted aldehydes with a diphenylamine ketone derivative, specifically 1-(3-((3,4-difluorophenyl)amino)phenyl)ethan-1-one,(RM) in the presence of potassium hydroxide (KOH) as the base and…
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The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Three submucosal neuron classes in the small intestine
To achieve an unbiased view of the neuronal diversity within the submucosal plexus in mice, we aimed to conduct scRNA-seq. While we previously have isolated and characterized myenteric neurons…
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Inflammation alters cognition after cancer immunotherapy
Cancer immunotherapy has transformed oncology, but it can cause cognitive dysfunction. Geraghty, Acosta-Alvarez et al. now dissect the neuro-immune mechanisms behind these impairments.
In mouse models of cancer, chimeric antigen receptor (CAR)-T…
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Stratification of G2 pancreatic neuroendocrine tumors using a Ten Percent Ki-67 index cut-off based on clinicopathological and molecular analyses
Clinicopathological and immunohistochemical data
The median age was 64 years (range, 36–86 years), and 44 of the 87 patients were male (51%). Distal pancreatectomy, pancreatoduodenectomy, and central pancreatectomy were performed for 41 (47%),…
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Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila
Li, K. & Gong, Z. Feeling hot and cold: thermal sensation in Drosophila. Neurosci. Bull. 33, 317–322 (2017).
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Rohacs, T., Thyagarajan, B. & Lukacs, V. Phospholipase…
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