Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the architecture of the genome and gene…
Category: 5. Biology
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Genetic analysis shows leprosy was endemic in pre-colonial America
Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent. Scientists from the Institut Pasteur, the CNRS, and the University of Colorado…
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Author Correction: Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
This study complied with all relevant ethical regulations. The research protocol was approved by the Institutional Ethics Review Board of the First Affiliated Hospital of China Medical University (No. [2022]366). The export of the relevant…
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Integrated distribution modeling resolves asynchrony between bat population impacts and occupancy trends through latent abundance
Probabilistic sampling grid and protocol
The NABat master sample8 is based on a grid-based sample frame with 10-km × 10-km cells (NABat grid cell), with each grid further sub-divided into 5-km × 5-km quadrants (quads, Fig. 1). The…
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Deep learning based motion correction in ultrasound microvessel imaging approach improves thyroid nodule classification
In-vivo thyroid dataset
This prospective study was conducted in accordance with the Health Insurance Portability and Accountability Act (HIPAA) and under the guidelines and regulations of the Mayo Clinic institutional review board (IRB)-approved…
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Impact of antibacterial therapeutic agents on biofilm-tissue interactions in a 3D implant-tissue-oral-bacterial-biofilm model
Henry, P. J. Oral implant restoration for enhanced oral function. Clin. Exp. Pharmacol. Physiol. 32, 123–127 (2005).
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Ritzert, B. Zahnimplantate zunehmend erste…
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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers
RNAi-mediated β-catenin inhibition results in potent CTNNB1 knockdown in vitro and in vivo
To study the effects of RNAi-mediated inhibition in β-catenin-mutated HCC, we utilized a novel siRNA that targets the CTNNB1 gene, with both mouse and…
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Granzyme B from maternal NK cells perturbs fetal brain development
Viral infection and the associated immune activation in mothers during pregnancy is linked to neurodevelopmental disorders in their offspring. But how perturbations at the maternal–fetal interface affect fetal brain development are unclear….
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Efficient and multiplexed somatic genome editing with Cas12a mice
Kersten, K., de Visser, K. E., van Miltenburg, M. H. & Jonkers, J. Genetically engineered mouse models in oncology research and cancer medicine. EMBO Mol. Med. 9, 137–153 (2017).
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