Anschütz, U., Becker, D. & Shabala, S. Going beyond nutrition: regulation of potassium homoeostasis as a common denominator of plant adaptive responses to environment. J. Plant Physiol. 171 (9), 670–687 (2014).
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Category: 5. Biology
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Precision multiplexed base editing in human cells using Cas12a-derived base editors
Evaluation of dCas12a-derived base editors for multiplex base editing
Previous studies reported editing frequencies ranging from 8.3% to 41% when employing dCas12a-derived BE systems to target five genomic loci in human cells simultaneously8,13….
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Integrating bulk RNA-seq and scRNA-seq analyses with machine learning to predict platinum response and prognosis in ovarian cancer
Siegel, R. L., Giaquinto, A. N. & Jemal, A. Cancer statistics, 2024. CA Cancer J. Clin. 74(1), 12–49 (2024).
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Lheureux, S., Braunstein, M. & Oza, A. M. Epithelial ovarian cancer:…
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Genetic compensation response contributes to Pleurodeles waltl limb regeneration
Ethics statement
All procedures were carried out in accordance with the Institutional Animal Care and Use Committee of Shandong Agricultural University (ethics approval No.: 2018-0125).
Animal husbandry, limb amputation, and chemical…
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Endolysosomal processing of neuron-derived signaling lipids regulates autophagy and lipid droplet degradation in astrocytes
Research in this study complies with all relevant ethical regulations and has been approved by the Institutional Animal Care & Use Committee and the Institutional Biosafety Committee of Rutgers University.
Antibodies and chemicals
Antibodies:…
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Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice
Animals
Specific pathogen-free male adult C57BL/6 mice aged approximately 6 weeks (17–20 g, n = 106) were obtained from the Beijing Vital River Laboratory Animal Technology. All experiments were approved by our local animal ethics…
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Soil microbial responses to multiple global change factors as assessed by metagenomics
Different prokaryotic composition under alternative GC scenarios
Soils are the most biodiverse habitat on the planet14, and contain an immense number of uncultivated microbial species not present in reference databases15. These unknown species can…
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A synbiotic improves performance and gut health in broiler chickens
In vitro studies
Prebiotics are used as substrates
In this research, four different oligosaccharides were utilized as prebiotics. The oligosaccharides included mannan oligosaccharide (Bio-Mos®), oligofructose (with an average degree of…
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A tiny Cambrian stem-mandibulate reveals independent evolution of limb tagmatization and specialization in early euarthropods
Comparisons to other euarthropod groups
The appendages in Primicaris reflect an artiopodan condition, which comprise a pair of uniramous antennae followed by a series of homonomous biramous appendages with their size decreasing towards rear…
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MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT
Mouse models
This research was regulated under the Animals (Scientific Procedures) Act 1986 Amendment Regulations 2012 following ethical review by the University of Cambridge Animal Welfare and Ethical Review Body (AWERB) for GDF15 fl/fl LysM-Cre…
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