Category: 5. Biology

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  • Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

    Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

    Theory

    The reaction space of the NBD is populated by the reaction scheme shown in Fig. 2a. It comprises 5 different states that are connected by 11 reaction equations of first and second order. We consider ATP hydrolysis an irreversible reaction…

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  • Detection of reproductive and hematobiochemical biomarkers to evaluate the impact of heavy metal exposure on brick kiln workers

    Detection of reproductive and hematobiochemical biomarkers to evaluate the impact of heavy metal exposure on brick kiln workers

    Ethical approval

    The study protocol was approved by the Bio-Ethical Committee of the Department of Zoology, Quaid-i-Azam University, Islamabad and has been assigned protocol #BEC-FBS-QAU2023-551. Additionally, the participants in the study…

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  • Bird mortality at wind farms in a tropical desert

    Bird mortality at wind farms in a tropical desert

    Study area

    The study was conducted during January 2020–September 2021 in 3000 km2 landscape of Indian Thar Desert in Jaisalmer, Rajasthan that included ~ 900 wind turbines (Fig. 6a). The region experiences arid bioclimate characterized by…

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  • Functional metabolites and inhibitory efficacy of kombucha beverage on pathogenic bacteria, free radicals and inflammation

    Functional metabolites and inhibitory efficacy of kombucha beverage on pathogenic bacteria, free radicals and inflammation

  • Paul Ross, R., Morgan, S. & Hill, C. Preservation and fermentation: past, present and future. Int. J. Food Microbiol. 79, 3–16. https://doi.org/10.1016/S0168-1605(02)00174-5 (2002).

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  • New Research Explains Why Diseases Affect Men and Women Differently

    New Research Explains Why Diseases Affect Men and Women Differently

    A new international study has revealed that most protein-level differences between men and women aren’t due to genetics alone. A major international study has uncovered new insights into why men and women often face different health risks,…

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  • Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury

    Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury

    AKI seriously jeopardizes human health worldwide due to high prevalence and mortality rates and unaffordable healthcare costs23. To date, there is no alternative to dialysis to prevent or treat AKI24. Renal IRI is one of the major causes of AKI

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  • The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

    The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

    Cell culture

    ESCs were maintained under standard conditions on gelatin-coated plates at 37 °C at 5% CO2 in Knockout DMEM (Thermo Fisher) supplemented with NEAA, GlutaMAX, penicillin/streptomycin (Thermo Fisher), 15% ESC-screened fetal bovine…

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