Translation of upstream open reading frames (uORFs) in mRNAs with multiple start codons can suppress downstream initiation sites. The researchers designed antisense RNA oligonucleotides (oligos) with a functional 5′ cap to bypass uORFs, which…
Category: 5. Biology
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The effects of LINC00324 on cell proliferation, migration, and invasion via autophagy in melanoma
Wei, C. Y. et al. Bioinformatics-based analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma. Oncogene 38(11), 1876–1891 (2019).
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Environmental metagenomics enhances detection of circulating viruses from live poultry markets in Cambodia
Peccia, J. et al. Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics. Nat. Biotechnol. 2020 38, 1164–1167 (2020).
Coker, R. J., Hunter, B. M., Rudge, J. W.,…
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Time-dependent deployment of medial prefrontal cortical representations in male mice
Sutton, R. S. & Barto, A. G. Introduction to reinforcement learning. (MIT press, Cambridge, 1998).
Corrado, G. & Doya, K. Understanding neural coding through the model-based analysis of decision making. J. Neurosci. 27, 8178–8180 (2007).
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Longitudinal multiomics analysis of endocrine therapy effects and gut microbiota in breast cancer recurrence
Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229–263 (2024).
Jordan, V. C….
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Reply to ‘Genome engineering for conservation might be a game changer but only with the incorporation of Indigenous voices’
Competing interests
M.A.S., L.B., A.L.K., B.S., M.J. and S.D.T. hold stock options in Colossal Biosciences. M.A.S. and L.B. are employed by Colossal Foundation. A.L.K., B.S. and M.J. are employed by…
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Soil biodiversity effects on ecosystems
Anthony, M. A., Bender, S. F. & Van Der Heijden, M. G. A. Enumerating soil biodiversity. Proc. Natl Acad. Sci. USA 120, e2304663120 (2023).
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van den Hoogen, J. et al. Soil nematode…
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Major features of parasite adaptation revealed by genomes of Plasmodium falciparum population samples archived for over 50 years
Amambua-Ngwa, A. et al. Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nat. Microbiol 8, 1213–1226 (2023).
Pelleau, S. et…
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Scientists Find Prehistoric Brain Circuit Still Controls Vision
Your ability to notice what matters visually comes from an ancient brain system over 500 million years old. The brain can make sense of the visual world even without relying on its most advanced outer layer, the cortex. A new study published in…
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This Simple Change Could Unlock Millions of Meals From the Sea
Allowing reef fish populations to recover could dramatically increase the global supply of sustainable seafood. The biggest gains would come in regions facing the most severe hunger, making reef restoration a powerful food solution. Coral Reefs…
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