The epidemiological observations that winter births and infections during early pregnancy are linked to an increased risk of schizophrenia and autism have coalesced into a paradigm that maternal immune activation (MIA) during gestation can…
Category: 5. Biology
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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
Lentiviral production
Lenti-X 293T (Takara Bio, 632180) cells were cultured in DMEM (high glucose; Life, 11965118) with 10% (vol/vol) FBS (Life, 26140079) and passaged with 1:10 split ratios at 90% confluency using TrypLE Express (Life, 12604013)….
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Engineering next-generation microfluidic technologies for single-cell phenomics
Regev, A. et al. The Human Cell Atlas. eLife 6, e27041 (2017).
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The Tabula Sapiens Consortium et al. The Tabula Sapiens: a multiple-organ,…
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RNA helicase unravels the secrets of germ granules
RNA helicase unravels the secrets of germ granules
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Astrocyte inflammasomes | Nature Immunology
Neuronal synaptic plasticity in the hippocampus is required for the formation of new neuronal connections during memory formation. In Immunity, Zengeler et al. report that inflammasome activation in hippocampus astrocytes regulates hippocampal…
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Milk NIR spectroscopy and Aquaphotomics novel diagnostic approach to Paratuberculosis in dairy cattle
Mycobacterium avium subspecies Paratuberculosis (MAP), a member of the Mycobacterium avium complex, causes Paratuberculosis or Johne’s disease (JD), a contagious, chronic, and usually fatal infection. Johne’s disease is classified as a group…
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NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910–6.
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Contrasting clonal and population genetic structure in two endangered Costa Rican Vanilla species of commercial interest
In our studies, the clonal nature of V. odorata and V. pompona has proven to be a critical factor in understanding the amount and distribution of genetic diversity. In comparing V. odorata and V. pompona, our study highlights sharp differences in…
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Correction: DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity
Correction: DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity
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GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model
Brandebura, A. N., Paumier, A., Onur, T. S. & Allen, N. J. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat. Rev. Neurosci. 24, 23–39 (2023).
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