The systematic workflow diagram (Fig. 2) comprehensively illustrates the operational pipeline of our detection system, encompassing critical modules including electrode modification, electrochemical measurement, feature engineering, and data…
Category: 5. Biology
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Loss of colonic fidelity enables multilineage plasticity and metastasis
Mouse studies
All in vivo experiments were performed in accordance with the UK Home Office regulations (project licence: PP9016178, PP7510272 and PP3908577) and were subject to local ethics review by the animal welfare and ethics board of the…
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Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression
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Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro
Deep cell atlas of the human lung
To build a deep human lung cell atlas, we profiled 311,748 cells from 8 normal explanted human lungs, from individuals of both genders (5 females, 3 males), a broad age range (3 months to 66 years old) and…
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A versatile information retrieval framework for evaluating profile strength and similarity
Profile evaluation as information retrieval
A fundamental goal of profiling analysis is to identify biologically meaningful relationships between samples by comparing their phenotypic signatures. One important application of this is the ability to…
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The effects of inhibiting IRE1α on the viability of ovarian granulosa cells
Cells and ethical approval
In this study, the human granulosa cell line (SVOG) (BeNa Culture Collection, BNCC340889) was established by transfecting primary human granulosa cells (hGL) with the non-tumorigenic immortalized SV40 large T antigen….
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Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites in mice
Male mice exhibit less protection after prime-and-trap vaccination
To assess the influence of sex on the efficacy on liver stage malaria vaccines, we utilized a two-dose heterologous P&T regimen16 in male and female BALB/cJ mice. This P&T regimen…
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Single-molecule parallel analysis for rapid exploration of sequence space
Roy, R., Hohng, S. & Ha, T. A practical guide to single-molecule FRET. Nat. Methods 5, 507–516 (2008).
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Joo, C., Balci, H., Ishitsuka,…
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Distinct modulation of microsaccades in motor planning and covert attention
Posner, M. I. Orienting of attention. Q. J. Exp. Psychol. 32, 3–25 (1980).
Carrasco, M. Visual attention: The past 25 years. Vis. Res. 51, 1484–1525 (2011).
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RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma
Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA 71, 209–249 (2021).
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Yang, C. et al….
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