To showcase the potential of our approaches in real-life data, we applied the methods to the IBD dataset with 66 280 observations and 38 825 SNPs after preprocessing. We divided the data into train (65%), validation (20%) and test (15%). As in…
Category: 5. Biology
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Resilient cortical maps | Nature Neuroscience
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Genomic and metabolic network properties in thermophiles and psychrophiles compared to mesophiles
Genomic insights into thermophiles and psychrophiles
A comparative analysis of the genomic features of 59 species, from 22 taxonomy phyla, divided into the three environmental groups; thermophiles, psychrophiles, and mesophiles was conducted to…
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Phytic acid impairs macrophage inflammatory response in Echinococcus multilocularis infection
Mice and E. multilocularis infection
Five female and five male 10–11 week old C57BL/6JRj mice (Janvier Labs) were infected with 1000 Echinococcus multilocularis eggs by oral gavage in the Biosafety Level 3 (BSL-3) facilities at the Medical…
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Epistasis in cardiac traits | Nature Cardiovascular Research
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Disulfidptosis meets antitumour immunity | Nature Cell Biology
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Epistasis regulates genetic control of cardiac hypertrophy
Study participants
The use of human participants (IRB-4237) and human-derived induced pluripotent stem cells (SCRO-568) in this study has been approved by the Stanford Research Compliance Office. The UKBB received ethical approval from the North…
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Immunogenicity of primary and booster MenACWY-TT vaccination in older adults and the importance of IgM
Study population
Out of the 5570 invitations sent to eligible older adults, 512 individuals (9.5%) expressed interest in participating in the study and 223 participants were included to receive a primary MenACWY-TT dose (Fig. 1). Following the…
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Control of epithelial tissue organization by mRNA localization
Net1 mRNA localizes to the basal cell membrane in epithelia
To probe the function of protrusion-localized mRNAs in epithelia in vivo, we first surveyed the subcellular localization of several protrusion-localized mRNAs12,21 (i.e., Net1, Cyb5r3,…
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Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast
Sucrose phosphorolysis replaces the native hydrolysis route
Sucrose metabolism in yeast is governed by several key genes: the extracellular sucrose-hydrolysing enzyme gene SUC2, the maltase genes MAL12 and MAL32, isomaltase genes IMA1-5, and…
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