Chemical synthesis of KMR-14-03 and KMR-14-14
General chemistry
Reagents and solvents were purchased from Sigma Aldrich, with building blocks from Fluorochem or Activate Scientific. All reactions were monitored by thin layer chromatography using…
Category: 5. Biology
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Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression
Smal, I., Loog, M., Niessen, W. & Meijering, E. Quantitative comparison of spot detection methods in fluorescence microscopy. IEEE Trans. Med. Imaging 29, 282–301 (2010).
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crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors
Model development and workflow
The crossNN model architecture (Fig. 1a) relies on a perceptron, implemented as a single-layer NN using PyTorch (see ‘Model training’ in Methods). The network architecture consists of an input layer and an output…
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Translation suppresses exogenous target RNA-mediated microRNA decay
TDMD triggers preferentially localize to noncoding regions of RNA
The rapidly expanding field of ZSWIM8-dependent TDMD research is elucidating mechanisms that regulate miRNA stability in animals. The accurate identification of endogenous miRNA…
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Machine learning to predict penumbra core mismatch in acute ischemic stroke using clinical note data
Study Design & Patient Population
This was a retrospective model derivation study using patient data from the Mount Sinai Health System (MSHS), a multi-site, tertiary-care hospital network in New York City comprising 2 academic medical centers and…
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Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control
Reference material, chemicals & consumables
Garetosmab, Landogrozumab and Stamulumab reference materials were purchased from MedChemExpress (New Jersey, USA). Sotatercept, Elritercept, Luspatercept, Ramatercept and Apitegromab reference materials…
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Author Correction: Small language models learn enhanced reasoning skills from medical textbooks
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Investigating the mechanism of Gentiopicroside in rheumatoid arthritis through network pharmacology, molecular docking, and experimental validation
Potential GEN targets on RA
Here, we obtained 120 potential targets of GEN from the TCMSP database. Through the Genecards and Disgenet databases, we identified 6,145 disease targets associated with RA. By intersecting the two datasets, we…
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Deferential nephrotoxicity effect of lanthanum oxide nanoparticle responses to concentration and time in vivo
This study aimed to investigate the nephrotoxic effects of lanthanum oxide nanoparticles using a dose- and time-dependent approach. Our findings reveal significant kidney dysfunction and inflammation associated with La₂O₃ NP exposure,…
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Extracellular ligand-responsive translational regulation of synthetic mRNAs using engineered receptors
Development of Tobacco Etch Virus protease (TEVp)-sensitive translational regulator protein
To develop this system, we focused on G protein-coupled receptors (GPCRs), the largest family of cell surface receptors, which recognize a diverse range of…
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