Clinical and neuropathological exams
We studied a Spanish Caucasian family with a known history of Parkinsonism in five members from three generations, segregating in an autosomal dominant manner. Neurological examination was performed in the…
Category: 5. Biology
-
A macrozoobenthic data set of the Black Sea northwestern shelf
Kristensen, E. & Kostka, J. E. Macrofaunal burrows and irrigation in marine sediment: Microbiological and biogeochemical interactions. in Coastal and Estuarine Studies (eds. Kristensen, E., Haese, R. R. & Kostka, J. E.) vol. 60 125–157
Continue Reading
-
A large-scale curated and filterable dataset for cryo-EM foundation model pre-training
Yip, K. M., Fischer, N., Paknia, E., Chari, A. & Stark, H. Atomic-resolution protein structure determination by cryo-em. Nature 587, 157–161 (2020).
Google Scholar
…Continue Reading
-
Merkel cell stimulation in fear and sensory signaling
Fenster RJ, Lebois LAM, Ressler KJ, Suh J. Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man. Nat Rev Neurosci. 2018;19:535–51.
Google…
Continue Reading
-
Integrating spatial and single-cell transcriptomics to characterize mouse long bone fracture healing process
Spatial dynamics of cellular interactions in bone fracture healing
We generated fractures on the femurs of male mice at 12 weeks of age and then collected and processed the tissues for spatial transcriptomics on Day 0 before fracture and at Days 5…
Continue Reading
-
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma
Antibody, chemicals, primers, and siRNA/sh RNA sequence information used in this study are listed in Tables S1–S3.
Dual-luciferase reporter assays
Huh7 cells were transiently transfected with Flag-LMNB2 and pCMV-Vector using Lipo6000 Transfection…
Continue Reading
-
High fat diet induces gastric production of fibroblast growth factor 23 (FGF23)
Animal model and maintenance
The animal experiments in this study were approved by the state of Baden-Württemberg, Germany, and were in accordance with the federal law for welfare of animals.
Male adult mice (B6129PF2/J background, JAX Stock…
Continue Reading
-
Systematic scoping review of external validation studies of AI pathology models for lung cancer diagnosis
Database searches resulted in 4423 studies, with 440 additional studies identified through other sources, including Google Scholar and a snowballing approach (Fig.1). After duplicates were removed, we screened 3851 titles and abstracts, and…
Continue Reading
-
MRG15 alternative splicing regulates CDK1 transcriptional activity in mouse cell senescence and myocardial regeneration
Isolation and culture of mouse embryonic fibroblasts (MEFs)
Mouse embryonic fibroblasts (MEFs) were isolated from E13.5 embryos of C57BL/6 J mice following ethical guidelines. Embryos were collected aseptically and minced into small pieces after…
Continue Reading
-
Investigation of brain white matter and social cognition in schizophrenia and schizotypal personality disorder using neurite orientation dispersion and density imaging
Pulay AJ, Stinson FS, Dawson DA, Goldstein RB, Chou SP, Huang B, et al. Prevalence, correlates, disability, and comorbidity of DSM-IV schizotypal personality disorder: results from the wave 2 national epidemiologic survey on alcohol and related…
Continue Reading