Overall workflow of the image processing pipeline
Figure 1 illustrates the general workflow of the automated image acquisition and processing pipeline. The workflow, described in detail in the Methods section, begins with the generation of…
Category: 5. Biology
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Identifying hotspots of naturally regenerating forests
Using remotely sensed forest cover data spanning from 1990 to 2023, researchers at the University of Cambridge, Christopher Bousfield and David Edwards, mapped the spatial distribution and ages of regenerating tropical moist forests. This study,…
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Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
Wolf, N. K., Kissiov, D. U. & Raulet, D. H. Roles of natural killer cells in immunity to cancer, and applications to immunotherapy. Nat. Rev. Immunol. 23, 90–105 (2023).
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Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration
The spatiotemporal expression of PD patterning genes differs in PBs and DBs
To explore how patterning genes regulate RA signaling in PBs and DBs, we examined the expression of known RA-responsive homeobox genes, including Meis1 and Meis215,31. We…
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A chromosomal-level genome assembly of the tropical sea cucumber Stichopus fusiformiossa
Stricker, S. A. The fine structure and development of calcified skeletal elements in the body wall of holothurian echinoderms. J. Morphol. 188, 273–288 (1986).
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Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Ethical approval
Human studies were approved by the regional committee of ethics in Stockholm and adhered to the statuses of the Declaration of Helsinki (Ethical Permits nos. 2008/1748-31/2, 2011/668-31/3, 2015/1115-31 and 244/01). All patients…
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Proteomics analysis and immune profiling reveal regulators of PD-L1 in oesophageal squamous cell carcinoma
Thrift AP. Global burden and epidemiology of Barrett oesophagus and oesophageal cancer. Nat Rev Gastroenterol Hepatol. 2021;18:432–43.
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Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, et…
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Targeted RNA acetylation via a dCas13-guided engineered acetyl-transferase
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Yu, J. et al. Programmable RNA acetylation with CRISPR–Cas13. Nat. Chem. Biol.
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New insights into the physical principles behind embryo development
During embryonic development, thousands of cells divide and move collectively to sculpt the main body axes. Understanding the mechanisms that coordinate this collective behavior remains a significant challenge in biology and the…
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