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This is a summary of: Lim, J. X. et al. PD-1 receptor deficiency enhances CD30+ Treg cell function in…
Category: 5. Biology
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Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex
World Health Organization. Global Status Report on Alcohol and Health 2018 (World Health Organization, 2019).
Chikritzhs, T. & Livingston, M. Alcohol and the risk of injury. Nutrients 13, 2777 (2021).
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Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response
Li, W. et al. Clinical translation of long-acting drug delivery formulations. Nat. Rev. Mater. 7, 406–420 (2022).
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Kulkarni, T. A. et al. A year-long extended release…
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Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice
Hematopoietic stem cells (HSCs) reside at the apex of the blood hierarchy and play important roles throughout an organism’s lifespan in adapting to physiological demands1. However, aging leads to a…
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Multimodal whole slide image processing pipeline for quantitative mapping of tissue architecture and tissue microenvironment
Overall workflow of the image processing pipeline
Figure 1 illustrates the general workflow of the automated image acquisition and processing pipeline. The workflow, described in detail in the Methods section, begins with the generation of…
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Identifying hotspots of naturally regenerating forests
Using remotely sensed forest cover data spanning from 1990 to 2023, researchers at the University of Cambridge, Christopher Bousfield and David Edwards, mapped the spatial distribution and ages of regenerating tropical moist forests. This study,…
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Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
Wolf, N. K., Kissiov, D. U. & Raulet, D. H. Roles of natural killer cells in immunity to cancer, and applications to immunotherapy. Nat. Rev. Immunol. 23, 90–105 (2023).
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Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration
The spatiotemporal expression of PD patterning genes differs in PBs and DBs
To explore how patterning genes regulate RA signaling in PBs and DBs, we examined the expression of known RA-responsive homeobox genes, including Meis1 and Meis215,31. We…
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A chromosomal-level genome assembly of the tropical sea cucumber Stichopus fusiformiossa
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