Inspired by their remarkable success in many areas, foundation models have recently been in the spotlight for method development in computational biology. As an example, single-cell foundation models digest a massive corpus of data aiming to…
Category: 5. Biology
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Energizing leukaemia | Nature Reviews Cancer
Signals emanating from the bone marrow microenvironment are crucial for the survival, stem cell self-renewal capacity and pathogenesis of haematological malignancies. Yet, many of the local and direct interactions between stromal cells and…
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Intracellular protein editing | Nature Methods
Studying proteins in native cellular contexts provides a more realistic picture of their functions. Most available techniques for studying proteins in mammalian cells require the addition of a tag that enables tracking and visualization of the…
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Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition
Cell culture
Human GC MGC803 cells were obtained from Beyotime Biotech (Shanghai, China). Other human GC cell lines (AGS, HGC27, MKN45, SNU-1, and KATOIII) and human mesothelial cell line MET-5A were purchased from Procell Life Science and…
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Guinea pigs as embryo models
However, guinea pig and human physiologies share several similarities, such as a 6–7 day preimplantation period, cavitation and development of a bilaminar disc after implantation. To establish the guinea pig as a model organism to study human…
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Persistence over virulence in Yersinia pestis
Yersinia pestis, a zoonotic pathogen that spread from wild rodents to peridomestic rodents and humans, has caused three historic plague pandemics. Genomic evidence from ancient human remains reveals reduced copies of the virulence gene pla in…
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A new Mongolian tyrannosauroid and the evolution of Eutyrannosauria
Brusatte, S. L., Averianov, A., Sues, H.-D., Muir, A. & Butler, I. B. New tyrannosaur from the mid-Cretaceous of Uzbekistan clarifies evolution of giant body sizes and advanced senses in tyrant dinosaurs. Proc. Natl Acad. Sci. USA 113,…
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Vitamin D and Neonatal Development
A large-scale Danish study published in Lancet Psychiatry offers robust evidence linking neonatal vitamin D deficiency to an increased risk of neurodevelopmental disorders—namely, schizophrenia,…
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The global rule that predicts where life thrives—and where it fails
A simple rule that seems to govern how life is organized on Earth is described in a new study published on June 4 in Nature Ecology & Evolution.
The research team led, by Umeå University and involving the University of Reading, believe this rule…
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Study of monozygotic twins reveals genetic factors linked with differences in environmental sensitivity
An international team of researchers led by King’s College London have identified genetic factors that may make some individuals more or less sensitive to the environments they experience.
Published in Nature Human Behaviour, the…
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