Among the most pressing global environmental challenges, drought is certainly one of the most concerning owing to its increased frequency and intensity, posing a threat to primary productivity, food security and environmental health worldwide….
Category: 5. Biology
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Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma
Patient samples
This study complies with all relevant ethical regulations and was approved by the Institutional Review Boards at Johns Hopkins and the National Institutes of Health. Forty-two patients were retrospectively identified at Johns…
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Current economic and regulatory challenges in developing antibiotics for Gram-negative bacteria
Pulingam, T. et al. Antimicrobial resistance: prevalence, economic burden, mechanisms of resistance and strategies to overcome. Eur. J. Pharm. Sci. 170, 106103 (2022).
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Publisher Correction: Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota
Pal, C., Bengtsson-Palme, J., Kristiansson, E. & Larsson, D. G. The structure and diversity of human, animal and environmental resistomes. Microbiome 4, 54 (2016).
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Genome-wide analyses identify circAQR, a circular RNA suppressing proliferation but promoting migration and invasion in thyroid cancer
Substantial novel circRNAs
We searched the GEO database using the keywords “thyroid” and “high-throughput sequencing” and identified 204 datasets. Our exclusion criteria included “non-thyroid cancer tissues,” “non-RNA sequencing,”…
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Measuring the effects of regulatory variants in an endogenous context
Regulatory elements in the genome, such as enhancers and promoters, encode sequences that orchestrate when, in which cell types, and to what extent all human genes are expressed. The activities of these sequences are fine-tuned by their…
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Light-microscopy-based connectomics | Nature Methods
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QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy
Model structure
A system of ordinary differential equations (ODEs) was specified, consisting of 37 variables and 90 parameters. The model was built in a stepwise fashion by combining two published QSP models, one for the TDB mosunetuzumab24 and…
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