Reporting in Nature, McPherson et al. provide insights into why whole-genome doubling (WGD) is frequently observed in ovarian cancer. The team used single-cell DNA sequencing to analyze WGD events in 70 multi-site samples from a cohort of 41…
Category: 5. Biology
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Cancer stem cells and Lon-noncRNA promotes invasion, metastasis and tumor growth in breast cancer through regulation of signaling pathway
Study subjects
The study cohort comprised 30 patients diagnosed with metastatic breast cancer (MBC) who were evaluated and treated at the Baheya Foundation for Early Detection and Treatment of Breast Cancer, Egypt. All cases were confirmed through…
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Rules of partitioning | Nature Reviews Cancer
Membraneless compartments within cells that concentrate specific molecules, known as biomolecular condensates, are increasingly being recognized in controlling cancer-related processes, such as oncogenic transcription. Lyons et al. set out to…
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Development of a versatile chassis for the efficient production of diverse type II polyketides
Selection of the optimal host for heterologous expression of T2PKs
Through a comparative analysis of the functional characteristics across distinct organism hosts, we prioritized Streptomyces hosts as the initial focus for chassis development due…
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SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors
Kyle, R. A. et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N. Engl. J. Med. 356, 2582–2590 (2007).
Kyle, R. A. et al. A long-term study of prognosis in…
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A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity
GtACR1 variant Q46E
To gain insights into the functional differences between CrChR2 and GtACR1, we compared the existing X-ray structures57,58 of the central constriction sites, which represent the functional cores of…
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Long-range enhancers rely on LHX motifs
In mammals, some enhancers are capable of regulating target genes that are located a megabase away. However, the DNA sequences or chromatin features that permit this long-range activity are still elusive. In a truly remarkable study, Evgeny Kvon…
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Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning
Topographically positioned MEC neurons have distinct axonal projection patterns
In addition to the Adgrl2 topographical expression profile that is observed in the MEC, Adgrl2 expression is confined to select neurons in superficial II/III layers [
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Oversized nanodiscs for combined structural and functional investigation of multicomponent membrane protein systems
Fagerberg, L., Jonasson, K., von Heijne, G., Uhlén, M. & Berglund, L. Prediction of the human membrane proteome. Proteomics 10, 1141–1149 (2010).
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Overington, J. P.,…
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Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting
Study participants and sampling
Mother–child pairs during the first year of life
Mother–child pairs from an urban clinic, The Gambia, participating in a trial of maternal immunization with MenAfriVAC were included (NCT03746665). All samples…
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