Roeder, R. G. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21(9), 327–335 (1996).
Thomas, M. C. & Chiang, C. M. The general transcription…
Category: 5. Biology
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Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma
Single-cell RNA sequencing analysis
Preprocessing and clustering methods
The scRNA-seq dataset used for downstream analysis included 24 PDAC and 11 normal pancreas samples from ref. 23 and 23 PDAC and 5 normal pancreas samples from ref. 24. Data…
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Author Correction: Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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C1q-dependent clearance of alpha-synuclein allows macrophages to transiently limit enteric synucleinopathy in male mice
Beach, T. G. et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 119, 689–702 (2010).
Rao, M. & Gershon,…
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From in-silico QSAR modeling to in-vitro MTT assay: experimental validation of novel uPAR leads for triple-negative breast cancer (TNBC) and skin cancer
Siegel, R. L., Giaquinto, A. N., Jemal, A. & Cancer statistics, 2024. CA: A Cancer Journal for Clinicians 74, 12–49, https://doi.org/10.3322/caac.21820 (2024).
Guan, X. Cancer metastases: challenges and opportunities. Acta Pharm. Sinica B. 5,…
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Carbon Dots and mesoporous silica nanocomposites improve spray-induced gene silencing to suppress plant RNA and DNA viruses
Savary, S. et al. The global burden of pathogens and pests on major food crops. Nat. Ecol. Evol. 3, 430–439 (2019).
Velasco, L., Ruiz, L., Galipienso, L., Rubio, L. & Janssen, D. A….
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Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Cell treatment for global proteomics experiments
CAL-51 cells were cultured in DMEM (Gibco) supplemented with 10% FBS (Corning). For global proteomics profiling experiments, 12-well plates of subconfluent 70–90% CAL51 cells were incubated for…
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Denitrification looks different in rivers versus streams
Human activities add large quantities of nitrogen to the environment, much of which gets washed into streams and rivers. These waterways transport some of that nitrogen to the oceans, but they also remove a significant portion of it through a…
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Woodland birds living among native trees produce more chicks, study shows
Native trees, such as oaks, have long held a special place in our culture and countryside. Now, researchers have shown that these trees are also important to woodland birds and their offspring.
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Scientists Discover the Body’s Natural “Off Switch” for Inflammation
A human study reveals how naturally occurring fat-derived molecules help switch off inflammation. Researchers at University College London (UCL) have identified an important biological process that helps the body bring inflammation to an end, a…
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