Category: 5. Biology

Over one billion genetic variants have been identified in humans. However, most of these variants lack functional characterization and whether they affect human health remains unclear. Multiplexed assays of variant effect (MAVEs) can close this…

Many published studies use entrapment incorrectly

Before describing various methods for entrapment analyses, it is important to distinguish between methods that provide estimated upper bounds versus lower bounds of the FDP, and understand their…

Patients and specimens

Human HCC tissues and liver tissues were obtained from pathologist-certified HCC patients who underwent curative resection at Zhongshan Hospital, Fudan University, from April 2022 to January 2023. These patients did not…

In this study, CT-based radiomics parameters demonstrated the ability to predict LNM in patients with T1/2 stage ESCC, and the radiomics features of GTV and CTV were complementary. Meanwhile, the screening and combination of radiomics parameters…

Animal procedures

Medaka d-rR strain was used in this study. Fertilized embryos were raised according to standard protocols²³ at 28 °C. Developmental stages were determined according to previously published guidelines (Iwamatsu 2004)….

Overview of stClinic

stClinic dissects cellular niches in diverse populations by integrating SMSMO and clinical data through five key components (Fig. 1a–d): (i) learning batch-corrected features from multi-slice data using dynamic graphs; (ii)…

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This is a summary of: Ji, T. et al. Remote on–off switching of protein activity by intrinsically disordered…

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Chen, D. et al. Pioneer factor ETV2 safeguards endothelial cell specification by…